1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Tandospirone

Tandospirone (Synonyms: SM-3997)

Cat. No.: HY-14558 Purity: 99.41%
Handling Instructions

Tandospirone (SM-3997) is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms.

For research use only. We do not sell to patients.

Tandospirone Chemical Structure

Tandospirone Chemical Structure

CAS No. : 87760-53-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 125 In-stock
Estimated Time of Arrival: December 31
10 mg USD 114 In-stock
Estimated Time of Arrival: December 31
50 mg USD 516 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Tandospirone (SM-3997) is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms[1][2].

IC50 & Target[1]

5-HT1A Receptor

27 nM (Ki)

In Vitro

Tandospirone is approximately two to three orders of magnitude less potent at 5-HT2, 5-HT1C, α1-adrenergic, α2-adrenergic and dopamine D1 and D2 receptors (Ki values ranging from 1300 to 41000 nM) than at 5-HT1A[1].
Tandospirone activats postsynaptic 5-HT1A receptor coupled with G-protein (Gi/o), resulting in inhibition of protein kinase A (PKA)-mediated protein phosphorylation and neuronal activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tandospirone (10-80 mg/kg; i.p.) inhibited freezing behavior in the conditioned fear stress-induced freezing behavior rat model[3].
Tandospirone exhibits the anxiolytic effect dependent on the plasma concentration of at 0.5 hours but not 4 hours[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old male Sprague-Dawley rats (260-300 g), conditioned fear stress-induced freezing behavior rat model[3]
Dosage: 10 mg/kg, 20 mg/kg, 40 mg/kg, 80 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited freezing behavior in a dose-dependent manner.
Clinical Trial
Molecular Weight

383.49

Formula

C₂₁H₂₉N₅O₂

CAS No.

87760-53-0

SMILES

O=C1[[email protected]]2([H])[[email protected]]([[email protected]]3CC[[email protected]@H]2C3)([H])C(N1CCCCN(CC4)CCN4C5=NC=CC=N5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (130.38 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6076 mL 13.0381 mL 26.0763 mL
5 mM 0.5215 mL 2.6076 mL 5.2153 mL
10 mM 0.2608 mL 1.3038 mL 2.6076 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.41%

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Keywords:

TandospironeSM-3997SM3997SM 39975-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-hydroxytryptamineanxietydisorderdepressionParkinson's diseaseschizophreniacentralnervoussystemCNSdisordersInhibitorinhibitorinhibit

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Tandospirone
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HY-14558
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