1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. Tandospirone hydrochloride

Tandospirone hydrochloride  (Synonyms: SM-3997 hydrochloride)

Cat. No.: HY-110053
Handling Instructions

Tandospirone (SM-3997) hydrochloride is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone hydrochloride has anxiolytic and antidepressant activities. Tandospirone hydrochloride can be used for the research of the central nervous system disorders and the underlying mechanisms.

For research use only. We do not sell to patients.

Tandospirone hydrochloride Chemical Structure

Tandospirone hydrochloride Chemical Structure

CAS No. : 99095-10-0

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Description

Tandospirone (SM-3997) hydrochloride is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone hydrochloride has anxiolytic and antidepressant activities. Tandospirone hydrochloride can be used for the research of the central nervous system disorders and the underlying mechanisms[1][2][3].

IC50 & Target

5-HT1A Receptor

27 nM (Ki)

In Vitro

Tandospirone (SM-3997) hydrochloride is approximately two to three orders of magnitude less potent at 5-HT2, 5-HT1C, α1-adrenergic, α2-adrenergic and dopamine D1 and D2 receptors (Ki values ranging from 1300 to 41000 nM) than 5-HT1A[1].
Tandospirone hydrochloride is essentially inactive at 5-HT1B receptors; 5-HT uptake sites; beta-adrenergic, muscarinic cholinergic, and benzodiazepine receptors[1].
Tandospirone hydrochloride activates postsynaptic 5-HT1A receptor coupled with G-protein (Gi/o), resulting in inhibition of protein kinase A (PKA)-mediated protein phosphorylation and neuronal activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tandospirone (SM-3997) hydrochloride (10-80 mg/kg; i.p.) inhibits freezing behavior in the conditioned fear stress-induced freezing behavior rat model[3].
Tandospirone hydrochloride exhibits the anxiolytic effect dependent on the plasma concentration of at 0.5 hours but not 4 hours[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old male Sprague-Dawley rats (260-300 g), conditioned fear stress-induced freezing behavior rat model[3]
Dosage: 10 mg/kg, 20 mg/kg, 40 mg/kg, 80 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited freezing behavior in a dose-dependent manner.
Clinical Trial
Molecular Weight

419.95

Formula

C21H30ClN5O2

CAS No.
SMILES

O=C1[C@@]2([H])[C@](C(N1CCCCN3CCN(C4=NC=CC=N4)CC3)=O)([H])[C@H]5C[C@@H]2CC5.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Tandospirone hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tandospirone hydrochloride
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