Tandospirone hydrochloride
Based on 3 publication(s) in Google Scholar
Tandospirone (SM-3997) hydrochloride is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone hydrochloride has anxiolytic and antidepressant activities. Tandospirone hydrochloride can be used for the research of the central nervous system disorders and the underlying mechanisms.
For research use only. We do not sell to patients.
- CAS No.: 99095-10-0
- Formula: C21H30ClN5O2
- Molecular Weight:419.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tandospirone hydrochloride
MoreAll 5-HT Receptor Isoforms
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Biological Activity
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5-HT1A Receptor |
5-HT1A Receptor 27 nM (Ki) |
Tandospirone (SM-3997) hydrochloride is approximately two to three orders of magnitude less potent at 5-HT2, 5-HT1C, α1-adrenergic, α2-adrenergic and dopamine D1 and D2 receptors (Ki values ranging from 1300 to 41000 nM) than 5-HT1A[1].
Tandospirone hydrochloride is essentially inactive at 5-HT1B receptors; 5-HT uptake sites; beta-adrenergic, muscarinic cholinergic, and benzodiazepine receptors[1].
Tandospirone hydrochloride activates postsynaptic 5-HT1A receptor coupled with G-protein (Gi/o), resulting in inhibition of protein kinase A (PKA)-mediated protein phosphorylation and neuronal activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Tandospirone hydrochloride exhibits the anxiolytic effect dependent on the plasma concentration of at 0.5 hours but not 4 hours[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Seven-week-old male Sprague-Dawley rats (260-300 g), conditioned fear stress-induced freezing behavior rat model[3]
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Dosage:10 mg/kg, 20 mg/kg, 40 mg/kg, 80 mg/kg
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Administration:Intraperitoneal injection
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Result:Inhibited freezing behavior in a dose-dependent manner.
Chemical Information
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CAS No. 99095-10-0
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Molecular Weight 419.95
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Formula C21H30ClN5O2
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SMILES
O=C1[C@@]2([H])[C@](C(N1CCCCN3CCN(C4=NC=CC=N4)CC3)=O)([H])[C@H]5C[C@@H]2CC5.Cl
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Synonyms
SM-3997 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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NPJ Digit Med
Tandospirone augments cisplatin treatment by lowering cholesterol and managing distress in NSCLC patients. [Abstract]2025 Nov 17;8(1):663. PMID: 41249389 -
Pharmacology
Pharmacological Characteristics of Anxiolytics on Acetylcholine-Induced Contractions in Rat Detrusor Smooth Muscle. [Abstract]2020;105(7-8):369-376. PMID: 31655826 -
Neurosci Lett
Pre-treatment with Tandospirone attenuates fentanyl-induced respiratory depression without affecting the analgesic effects of fentanyl in rodents. [Abstract]2022 Feb 6:771:136459. PMID: 35041907
Purity & Documentation
References
[1]. Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28(2):99-109. [Content Brief]
[2]. Xuefei Huang, et al. Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. Oncotarget. 2017 Nov 24; 8(60): 102705–102720. [Content Brief]
[3]. Kyoko Nishitsuji, et al. The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress. Eur Neuropsychopharmacol. 2006 Jul;16(5):376-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tandospirone hydrochloride Related Classifications
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