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  2. Jatrorrhizine chloride

Jatrorrhizine chloride 

Cat. No.: HY-N0740 Purity: >98.0%
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Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants. Jatrorrhizine chloride exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons.

For research use only. We do not sell to patients.

Jatrorrhizine chloride Chemical Structure

Jatrorrhizine chloride Chemical Structure

CAS No. : 6681-15-8

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
20 mg USD 140 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine chloride exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2].

IC50 & Target

Uptake-2 transporter[1]

In Vitro

Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters[1].
Jatrorrhizine chloride significantly inhibits the plasma membrane monoamine transporter (PMAT) -mediated MPP+ uptake in a concentration-dependent manner with an IC50 value of 1.05 μM[1].
Jatrorrhizine chloride demonstrates a more powerful inhibition on serotonin (5-HT) and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT[1].
Jatrorrhizine chloride attenuates the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons[2].

Molecular Weight

373.83

Formula

C₂₀H₂₀ClNO₄

CAS No.

6681-15-8

SMILES

COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6750 mL 13.3751 mL 26.7501 mL
5 mM 0.5350 mL 2.6750 mL 5.3500 mL
10 mM 0.2675 mL 1.3375 mL 2.6750 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

JatrorrhizineOthersInhibitorinhibitorinhibit

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Jatrorrhizine chloride
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HY-N0740
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