2. Others Immunology/Inflammation Metabolic Enzyme/Protease Apoptosis NF-κB Neuronal Signaling
  3. Insecticide SOD Glutathione Peroxidase Reactive Oxygen Species (ROS) Cholinesterase (ChE)
  4. Methiocarb

Methiocarb (Mercaptodimethur) is an orally active carbamate insecticide. Methiocarb exerts dose-dependent toxic effects on onions. In addition to inhibiting acetylcholinesterase to induce cholinergic excitation, Methiocarb can induce lipid peroxidation in liver, kidney, brain and testicular tissues and alter reduced glutathione levels by generating ROS. Methiocarb can be used for agricultural pest control and research on oxidative stress-related cellular damage in mammals.

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Methiocarb

Methiocarb Chemical Structure

CAS No. : 2032-65-7

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Methiocarb Related Antibodies

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Description

Methiocarb (Mercaptodimethur) is an orally active carbamate insecticide. Methiocarb exerts dose-dependent toxic effects on onions. In addition to inhibiting acetylcholinesterase to induce cholinergic excitation, Methiocarb can induce lipid peroxidation in liver, kidney, brain and testicular tissues and alter reduced glutathione levels by generating ROS. Methiocarb can be used for agricultural pest control and research on oxidative stress-related cellular damage in mammals[1][2].

In Vitro

Methiocarb (2.5-7.5 mg/L; 72 h) exerts dose-dependent toxic effects on Allium cepa L. bulbs, including reducing rooting rate, root length and weight gain rate, increasing micronucleus rate, chromosome damage degree and MDA level, decreasing mitotic index, and elevating SOD and CAT activities, with the strongest effects observed at the concentration of 7.5 mg/L[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methiocarb Related Antibodies
In Vivo

Methiocarb (2-25 mg/kg; i.g.; once daily; 1-28 days) induces lipid peroxidation in the liver, kidney, brain and testis of rats, and disrupts their glutathione levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar Albino (male, 12-13 weeks old, 160 ± 20 g)[2]
Dosage: 25 mg/kg (1-day treatment); 10 mg/kg (5-day treatment); 2 mg/kg (28-day treatment)
Administration: i.g.; once (1-day); daily (5-day, 28-day)
Result: Increased LPO in the liver, kidney, brain and testis after 1, 5 and 28 days treatment, with the most significant increase in the brain.
Significantly elevated GSH levels in all the above tissues after 1 day of treatment but significantly decreased after 5 and 28 days of treatment, and the decrease in GSH levels in the kidney, brain and testis was more pronounced than that in the liver.
Molecular Weight

225.31

Formula

C11H15NO2S
CAS No.
SMILES

O=C(NC)OC1=CC(C)=C(SC)C(C)=C1
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Storage

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References
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Methiocarb Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methiocarb2032-65-7MercaptodimethurInsecticideSODGlutathione PeroxidaseReactive Oxygen Species (ROS)Cholinesterase (ChE)Superoxide Dismutaselipid peroxidationmale Wistar ratsInhibitorinhibitorinhibit

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