Kasugamycin hydrochloride
Based on 1 publication(s) in Google Scholar
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 19408-46-9
- Formula: C14H26ClN3O9
- Molecular Weight:415.82
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Kasugamycin hydrochloride
MoreAll Antibiotic Isoforms
More
Biological Activity
Kasugamycin hydrochloride (1 mM) inhibits P-site tRNA binding through destabilizing mRNA[1].
Kasugamycin hydrochloride (50 μg/mL) decreases the mistranslation rates of asparagine-to-aspartate and glutamine-to-glutamate[3].
Kasugamycin hydrochloride (0-100 μg/mL) reduces mycobacterial rifampicin phenotypic resistance in wild-type and high mistranslating gatA mutant mycobacterial strains[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lung burden of Mtb-infected mice[3]
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Dosage:400 mg/kg
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Administration:Intraperitoneal injection (i.p.) for 2 weeks
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Result:Resulted in dose-dependent concentration-time profiles in plasma with rapid clearance of M. tuberculosis.
Increased Rifampicin (HY-B0272) susceptibility by 30-fold.
Chemical Information
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CAS No. 19408-46-9
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Appearance Solid
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Molecular Weight 415.82
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Formula C14H26ClN3O9
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Color Off-white to light yellow
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SMILES
OC(C(N[C@@H](C[C@@H]1N)[C@@H](C)O[C@]1([H])O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]2O)=N)=O.[H]Cl
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Synonyms
Ksg hydrochloride
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Initial Source
Streptomyces kasugaensis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Mol Biosci
Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases. [Abstract]2021 Apr 7:8:640356. PMID: 33898519
Solvent & Solubility
H2O : 25 mg/mL (60.12 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Schluenzen F, et al. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol. 2006 Oct;13(10):871-8. [Content Brief]
[2]. Schuwirth BS, et al. Structural analysis of kasugamycin inhibition of translation. Nat Struct Mol Biol. 2006 Oct;13(10):879-86. [Content Brief]
[3]. Chaudhuri S, et al. Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation. Elife. 2018 Aug 28;7:e36782. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.4049 mL | 12.0244 mL | 24.0489 mL | 60.1222 mL |
| 5 mM | 0.4810 mL | 2.4049 mL | 4.8098 mL | 12.0244 mL | |
| 10 mM | 0.2405 mL | 1.2024 mL | 2.4049 mL | 6.0122 mL | |
| 15 mM | 0.1603 mL | 0.8016 mL | 1.6033 mL | 4.0081 mL | |
| 20 mM | 0.1202 mL | 0.6012 mL | 1.2024 mL | 3.0061 mL | |
| 25 mM | 0.0962 mL | 0.4810 mL | 0.9620 mL | 2.4049 mL | |
| 30 mM | 0.0802 mL | 0.4008 mL | 0.8016 mL | 2.0041 mL | |
| 40 mM | 0.0601 mL | 0.3006 mL | 0.6012 mL | 1.5031 mL | |
| 50 mM | 0.0481 mL | 0.2405 mL | 0.4810 mL | 1.2024 mL | |
| 60 mM | 0.0401 mL | 0.2004 mL | 0.4008 mL | 1.0020 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Kasugamycin hydrochloride Related Classifications
HY-B1864A Related Classifications
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