2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118580
    RO-09-4609
    		Inhibitor
    RO-09-4609 exhibits antimicrobial activity, that inhibits Candida albicans, Trypanosoma brucei and Plasmodium vivax through inhibition of N-myristoyl transferase.
    RO-09-4609
  • HY-181002
    CDA-IN-5
    		Inhibitor
    CDA-IN-5 (Compound M-09) is a Chitin deacetylase inhibitor with a Ki of 27.5 μM against PstCDA. CDA-IN-5 is an antifungal agent. CDA-IN-5 can inhibit infection by Rhizoctonia solani, Pyricularia oryzae, and Botrytis cinerea and exhibits moderate control efficacy against rice sheath blight.
    CDA-IN-5
  • HY-W008927
    Fluoxastrobin
    		Inhibitor
    Fluoxastrobin is a fungicide. By binding to NAD-dependent epimerase/dehydratase, Fluoxastrobin interferes with electron transport, reduces ATP production and inhibits mycelial growth, thereby effectively controlling foliar diseases of tea plants. Fluoxastrobin induces oxidative stress by increasing ROS levels and lipid peroxidation, causes DNA damage and promotes apoptosis; meanwhile, it shows high acute toxicity to Danio rerio embryos and larvae. Fluoxastrobin can be used in research related to tea foliar diseases (including tea red leaf spot and tea gray leaf spot).
    Fluoxastrobin
  • HY-162559
    SDH-IN-16
    		Inhibitor
    SDH-IN-16 (compound 5aa) is a potent inhibitor of Succinate Dehydrogenase, with the IC50 of 1.62 μM. SDH-IN-16 displays a broad spectrum of antifungal activity against F. graminearum, B. cinerea, S. sclerotiorum, and R. solani, with the corresponding EC50 values of 0.12, 4.48, 0.33, and 0.15 μg/mL, respectively.
    SDH-IN-16
  • HY-B0935R
    Benzyl benzoate (Standard)
    		Inhibitor
    Benzyl benzoate (Standard) is the analytical standard of Benzyl benzoate. This product is intended for research and analytical applications. Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.
    Benzyl benzoate (Standard)
  • HY-W242821
    Methyl 3,4-dimethoxycinnamate
    		Inhibitor
    Methyl 3,4-dimethoxycinnamate is an inhibitor of uredospore germination. Methyl 3,4-dimethoxycinnamate also inhibits global DNA methylation in in Hep3B cells.
    Methyl 3,4-dimethoxycinnamate
  • HY-180927
    Antibacterial agent 316
    		Inhibitor
    Antibacterial agent 316 (Compound C1-15) is an antibacterial agent. Antibacterial agent 316 shows antibacterial activity against Xanthomonas oryzae pv oryzae, Xanthomonas axonopodis pv citri, Pseudomonas solanacearum with MICs ranging from 1.56 to 6.25 μg/mL. Antibacterial agent 316 shows antifungal activity against Rhizoctonia solani, Botrytis cinerea.
    Antibacterial agent 316
  • HY-125124
    Chamaejasmenin D
    		Inhibitor
    Chamaejasmenin D is an antimitotic and antifungal agent.
    Chamaejasmenin D
  • HY-179163
    CYP51-IN-29
    		Inhibitor
    CYP51-IN-29 (Compound B3) is a CYP51 inhibitor and antifungal agent. CYP51-IN-29 effectively suppresses the yeast-to-hyphal transition. CYP51-IN-29 exhibits potent antifungal activity against Candida albicans.
    CYP51-IN-29
  • HY-N14291
    4-Methoxy-p-toluquinone
    		Inhibitor
    4-Methoxy-p-toluquinone is a quinone antibiotic found in the fungus Coprinus siniilis, Lentinus degener. 4-Methoxy-p-toluquinone has anti-bacterial, mycobacterial and fungal effects, but is weak against Gram-negative bacteria. The serum will inactivate it.
    4-Methoxy-p-toluquinone
  • HY-B1460R
    Sulconazole mononitrate (Standard)
    		Inhibitor
    Sulconazole (mononitrate) (Standard) is the analytical standard of Sulconazole (mononitrate). This product is intended for research and analytical applications. Sulconazole mononitrate ((±)-Sulconazole mononitrate), an imidazole derivative, is a broad-spectrum fungicide. Sulconazole mononitrate can be used for the research of dermatomycoses, pityriasis versicolor, and cutaneous candidiasis.
    Sulconazole mononitrate (Standard)
  • HY-N13880
    Adustin
    		Inhibitor
    Adustin, an antifungal antibiotic, is a polypeptide with translation-inhibiting activity. Adustin inhibits translation in a cell-free rabbit reticulocyte lysate system with an IC50 of 0.34 μM.
    Adustin
  • HY-W392548
    1-O-(4-Hydroxybenzoyl)-glycerol
    		Inhibitor
    1-O-4-Hydroxybenzoyl-glycerol is an antimicrobial agent against Staphylococcus aureus, Escherichia coli, Saccharomyces cerevisiae, and Fusarium culmorum (20 mM, maximum inhibition rate: 70%). 1-O-(4-Hydroxybenzoyl)-glycerol stimulates low skin irritation.
    1-O-(4-Hydroxybenzoyl)-glycerol
  • HY-B0846R
    Dimethomorph (Standard)
    		Inhibitor
    Dimethomorph (Standard) is the analytical standard of Dimethomorph. This product is intended for research and analytical applications. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 µM.
    Dimethomorph (Standard)
  • HY-W741555
    Dechlorogriseofulvin
    		Inhibitor
    Dechlorogriseofulvin (7-Dechlorogriseofulvin) is an antibiotic, and exhibits inhibitory activity against various plant pathogenic fungi. Dechlorogriseofulvin inhibits Botrytis cinerea, Rhizoctonia solani, Pythium ultimum, and Sclerotinia sclerotiorum with MIC of 40.0 µg/ml, 43.9 µg/ml, 81.7 µg/ml, and 28.5 µg/ml, respectively.
    Dechlorogriseofulvin
  • HY-174390
    SDH-IN-29
    		Inhibitor
    SDH-IN-29 (Compound A33) is a SDH inhibitor with an IC50 of 0.0709 μM. SDH-IN-29 has a broad spectrum of antifungal activities (EC50s of 0.356, 0.798 and 0.146 μg/mL for Fusarium graminearum, Sclerotinia sclerotiorum, and Rhizoctonia solani, respectively). SDH-IN-29 has moderate to significant protective effects against rice blast, wheat scab and cucumber powdery mildew.
    SDH-IN-29
  • HY-N14322
    Mollisin
    		Inhibitor
    Mollisin is a quinone antibiotic with antifungal activity.
    Mollisin
  • HY-N14173
    Epiderstatin
    		Inhibitor
    Epiderstatin is a glutarimide antibiotic. Epiderstatin has the activity of inhibiting the filamentous division induced by epidermal growth factor (EGF), but does not inhibit EGF-receptor kinase. Epiderstatin has only weak antifungal activity and no antibacterial effect.
    Epiderstatin
  • HY-173402
    TPS1-IN-1
    		Inhibitor
    TPS1-IN-1 (Compound O1) is a highly potent and broad-spectrum TPS1 inhibitor. TPS1-IN-1 with IC50s of 14.73 μM for MoTPS1 (TPS1 of M oryzae) and 59.99 μM for BcTPS1 (TPS1 of B cinerea), respectively. TPS1-IN-1 exerts a broad-spectrum fungicidal effect by interfering with spore germination, appressorium formation, and turgor pressure accumulation of fungi. TPS1-IN-1 has good safety and has the potential to be a novel fungicide candidate compound.
    TPS1-IN-1
  • HY-N14013
    Chondramide A
    		Inhibitor
    Chondramide A has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities.
    Chondramide A
Cat. No. Product Name / Synonyms Application Reactivity