2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121245
    Capoamycin
    		Inhibitor
    Capoamycin is an antibiotic. Capoamycin shows antimicrobial and antitumor activity.
    Capoamycin
  • HY-B0842R
    Thiophanate-Methyl (Standard)
    		Inhibitor
    Thiophanate-Methyl (Standard) is the analytical standard of Thiophanate-Methyl. This product is intended for research and analytical applications. Thiophanate-Methyl is a systematic fungicide.
    Thiophanate-Methyl (Standard)
  • HY-17643R
    Oteseconazole (Standard)
    		Inhibitor
    Oteseconazole (Standard) is the analytical standard of Oteseconazole. This product is intended for research and analytical applications. Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes.
    Oteseconazole (Standard)
  • HY-172676
    GW461484A
    		Inhibitor
    GW461484A is a small-molecule inhibitor targeting Candida albicans Yck2, with an IC50 of 0.11 µM. It exhibits antifungal activity against C. albicans with a MIC80 of 12.5 µM. GW461484A holds potential for research on fungal diseases, such as drug-resistant Candida infections.
    GW461484A
  • HY-N12676
    Phoslactomycin E
    		Inhibitor
    Phoslactomycin E has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin E
  • HY-113532
    Isofusidienol A
    		Inhibitor
    Isofusidienol A (Compound 26) is a chromone compound. Isofusidienol A can be isolated from Artemisia vulgaris. Isofusidienol A has significant antibacterial activity against Bacillus subtilis. Isofusidienol A also has potent antifungal activity against Candida albicans. Isofusidienol A can be used for bacterial and fungal infections research.
    Isofusidienol A
  • HY-P5590
    Dermaseptin-S3
    		Inhibitor
    Dermaseptin-S3 is an antimicrobial peptide derived from frog skin against filamentous fungi.
    Dermaseptin-S3
  • HY-178340
    Antifungal agent 137
    		Inhibitor
    Antifungal agent 137 (Compound 4S) is an antifungal agent. Antifungal agent 137 inhibits Phomopsis sp. (PS), with an EC50 of 0.15 μg/mL. Antifungal agent 137 inhibits lanosterol 14α-demethylase (CYP51), with an IC50 of 5.00 μg/mL. Antifungal agent 137 disrupts the morphology of PS mycelia, impairs cell membrane integrity, and induces an increase in intracellular ROS levels, triggering oxidative stress. Antifungal agent 137 can be used for the study of fungal infection.
    Antifungal agent 137
  • HY-W742324
    Pyriofenone
    		Inhibitor
    Pyriofenone (IKF-309) is an arylphenyl ketone fungicide used primarily to control powdery mildew on crops such as cereals, rice, fruit trees, and vegetables. Pyriofenone has moderate efficacy against rice blast. Pyriofenone acts through preventive, residual, curative, rainfast, cross-stratum, and fumigant activities.
    Pyriofenone
  • HY-17381R
    Idarubicin hydrochloride (Standard)
    		Inhibitor
    Idarubicin (hydrochloride) (Standard) is the analytical standard of Idarubicin (hydrochloride). This product is intended for research and analytical applications. Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.
    Idarubicin hydrochloride (Standard)
  • HY-B0319R
    Tioconazole (Standard)
    		Inhibitor
    Tioconazole (Standard) is the analytical standard of Tioconazole. This product is intended for research and analytical applications. Tioconazole (UK-20349) is an antifungal imidazole derivative with broad spectrum activity. Tioconazole has inhibitory active aginst several dermatophytes and several yeasts with MIC50s <3.12 mg/L and <9 mg/L, respectively.
    Tioconazole (Standard)
  • HY-W021040S
    Fludioxonil-13C3
    		Inhibitor
    Fludioxonil-13C3 (CGA-173506-13C3) is 13C labeled Fludioxonil. Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells.
    Fludioxonil-<sup>13</sup>C<sub>3</sub>
  • HY-N14716
    Haematocin
    		Inhibitor
    Haematocin can inhibit the germination of Pyricularia oryzae spore.
    Haematocin
  • HY-P5593
    Dermaseptin-S2
    		Inhibitor
    Dermaseptin-S2 is an antimicrobial peptide derived from frog skin against filamentous fungi.
    Dermaseptin-S2
  • HY-W752450
    Hordatine A
    		Inhibitor
    Hordatine A is an active ingredient that can be extracted from barley. Hordatine A has antifungal activity. Hordatine A can be used for research on fungal infections.
    Hordatine A
  • HY-108012R
    ME1111 (Standard)
    		Inhibitor
    ME1111 (Standard) is the analytical standard of ME1111 (HY-108012). This product is intended for research and analytical applications. ME1111 is an antifungal agent that is active against dermatophytes. ME1111 is an inhibitor of the succinate dehydrogenase of Trichophyton species. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research.
    ME1111 (Standard)
  • HY-W078710
    Hydroxymethyl dioxoazabicyclooctane
    		Inhibitor
    Hydroxymethyl dioxoazabicyclooctane is commonly used in cosmetic research and development to control the growth of microorganisms (such as bacteria and fungi).
    Hydroxymethyl dioxoazabicyclooctane
  • HY-B1134R
    Imazalil (Standard)
    		Inhibitor
    Imazalil (Standard) is the analytical standard of Imazalil. This product is intended for research and analytical applications. Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.
    Imazalil (Standard)
  • HY-168998
    Yck2-IN-1
    		Inhibitor
    Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection.
    Yck2-IN-1
  • HY-100575R
    Acriflavine (Standard)
    		Inhibitor
    Acriflavine (Standard) is the analytical standard of Acriflavine (HY-100575). This product is intended for research and analytical applications. Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2.
    Acriflavine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity