Yck2-IN-1
Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection.
For research use only. We do not sell to patients.
- CAS No.: 401816-26-0
- Formula: C19H11FN4
- Molecular Weight:314.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 401816-26-0
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Molecular Weight 314.32
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Formula C19H11FN4
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SMILES
N#CC1=CN2N=C(C(C3=CC=NC=C3)=C2C=C1)C4=CC=C(C=C4)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Yck2-IN-1 Related Classifications
HY-168998 Related Classifications
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