2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N12389
    Quellenin
    		Inhibitor
    Quellenin is an anti-saprolegnia compound. Quellenin can be isolated from deep-sea fungus Aspergillus sp. YK-76
    Quellenin
  • HY-P0269A
    Magainin 1 TFA
    		Inhibitor
    Magainin 1 TFA (Magainin I TFA) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 TFA exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.
    Magainin 1 TFA
  • HY-123135
    Scirpusin B
    		Inhibitor
    Scirpusin B (compound 5) is a dimeric antioxidant isolated from Scirpus maritimus L.. Scirpusin B exhibits antitumor, antifungal, insecticidal, and plant growth inhibitory activities.
    Scirpusin B
  • HY-139669
    Antifungal agent 13
    		Inhibitor
    Antifungal agent 13 exhibits remarkable antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.25 mg/L.
    Antifungal agent 13
  • HY-N19724
    Buddledin A
    		Inhibitor
    Buddledin A is a 5-LOX inhibitor (IC50 = 50.4 μM) and a COX inhibitor (IC50 = 13.7 μM). Buddedin A inhibits arachidonic acid metabolism via the 5-LOX and COX pathways, suppresses fungal growth, and exerts toxic effects on fish. Buddedin A may play an ecological role in protecting plant roots and stem barks from fungal infection. Buddedin A can be used in studies related to fungal infections.
    Buddledin A
  • HY-W042191R
    Oxychlororaphine (Standard)
    		Inhibitor
    Oxychlororaphine (Standard) is the analytical standard of Oxychlororaphine. This product is intended for research and analytical applications. Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer[1][2].
    Oxychlororaphine (Standard)
  • HY-N3652
    Cuspidiol
    		Inhibitor
    Cuspidiol (compound 3) is a CH2Cl2 extract of Fagara zanthoxyloides Lam. Cuspidiol has antifungal and antioxidative activity.
    Cuspidiol
  • HY-146067
    β-Nor-lapachone
    		Inhibitor
    β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity.
    β-Nor-lapachone
  • HY-136384
    Diethofencarb
    		Inhibitor
    Diethofencarb is a fungicide with strong activity against Botrytis cinerea and Benzimidazole-resistant strains of Botryis spp. Diethofencarb has a role as an antifungal agrochemical.
    Diethofencarb
  • HY-135307
    SSF-109
    		Inhibitor
    SSF-109 is a broad-spectrum fungicide which has protective activity against plant disease. SSF-109 inhibits the biosynthesis of ergosterol at the 14α-demethylation step in Botrytis cinerea.
    SSF-109
  • HY-N12723
    Talaroderxine D
    		Inhibitor
    Talaroderxine D (compound 4) has biofilm inhibitory effect. Talaroderxine D shows antimicrobial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 2.1 and 8.3 μg/mL.
    Talaroderxine D
  • HY-P5696
    Xenopsin precursor fragment
    		Inhibitor
    Xenopsin precursor fragment is an antimicrobial peptide, and has antibacterial/antifungal (10-500 μg/mL) and anti-protozoal (MIC: 2-20 μg/mL) activity.
    Xenopsin precursor fragment
  • HY-176140
    Succinate dehydrogenase-IN-9
    		Inhibitor
    Succinate dehydrogenase-IN-9 (Compound Iik) is a succinate dehydrogenase inhibitor (IC50: 3.6 μM). Succinate dehydrogenase-IN-9 exhibits potent inhibitory activity against various fungal species (eg: inhibits S. sclerotiorum with an EC50 value of 1.14 μg/mL. Succinate dehydrogenase-IN-9 enhances the nitrate reductase activity, thereby facilitating plant growth.
    Succinate dehydrogenase-IN-9
  • HY-U00058R
    Diflucortolone valerate (Standard)
    		Inhibitor
    Diflucortolone valerate (Standard) is the analytical standard of Diflucortolone valerate. This product is intended for research and analytical applications. Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases.
    Diflucortolone valerate (Standard)
  • HY-125723A
    Echinocandin B (purity>85%)
    		Inhibitor
    Echinocandin B (purity>85%) (SL 7810 (purity>85%)) is a lipopeptide antifungal antibiotic. Echinocandin B (purity>85%) is produced by Aspergillus nidulans. Echinocandin B (purity>85%) inhibits β-1,3-glucan activity, thereby blocking the biosynthesis of fungal cell walls. Echinocandin B (purity>85%) exhibits activity against a variety of Aspergillus species.
    Echinocandin B (purity>85%)
  • HY-N12606
    Neodidymelliosides A
    		Inhibitor
    Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candida albicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines.
    Neodidymelliosides A
  • HY-N8726
    Neophellamuretin
    		Inhibitor
    Neophellamuretin is a flavonoid. Neophellamuretin inhibits Trichophyton sp. with an MIC value of 62.5 µg/mL.
    Neophellamuretin
  • HY-N18194
    Ducloudine C
    		Inhibitor
    Ducloudine C is an alkaloid present in the roots of Aconitum duclouxii with antifungal activity. Ducloudine C has an MIC of 128 μg/mL against Candida albicans.
    Ducloudine C
  • HY-N0765R
    Isoliquiritin (Standard)
    		Inhibitor
    Isoliquiritin (Standard) is the analytical standard of Isoliquiritin. This product is intended for research and analytical applications. Isoliquiritin, isolated from Licorice Root, inhibits angiogenesis and tube formation. Isoliquiritin also exhibits antidepressant-like, anti-oxidative, anti-Inflammatory effects and antifungal activity.
    Isoliquiritin (Standard)
  • HY-158054
    Antifungal agent 95
    		Inhibitor
    Antifungal agent 95 (Compound CN21b) is an antifungal agent for Sclerotinia sclerotiorum and Botrytis cinerea, with EC50s of 2.11 and 0.97 μM, respectively. Antifungal agent 95 exhibits antifungal activity against resistant B. cinerea strains, with EC50s less than 10 μM.
    Antifungal agent 95
Cat. No. Product Name / Synonyms Application Reactivity