Buddledin A 

Buddledin A is a 5-LOX inhibitor (IC₅₀ = 50.4 μM) and a COX inhibitor (IC₅₀ = 13.7 μM). Buddedin A inhibits arachidonic acid metabolism via the 5-LOX and COX pathways, suppresses fungal growth, and exerts toxic effects on fish. Buddedin A may play an ecological role in protecting plant roots and stem barks from fungal infection. Buddedin A can be used in studies related to fungal infections^[1][2][3].

Buddledin A potently inhibits COX activity in activated rat peritoneal leukocytes, with an IC₅₀ value of 13.7 μM^[1].
Buddledin A inhibits the activity of 5-LOX in activated rat peritoneal leukocytes, with an IC₅₀ of 50.4 μM^[1].
Buddledin A (12.5 mg/mL) inhibits the growth of Epidermophyton floccosum, Trichophyton interdigitale, Fusarium graminearum and Sordaria fimicola, with an MIC of 12.5 mg/mL^[2].
Buddledin A (10 mg/m, 25°C, after 5 to 7 days) inhibits the growth of Fusarium solani^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

276.37

C₁₇H₂₄O₃

62346-20-7

O=C(/C(C)=C/CC1)[C@H](OC(C)=O)[C@@]2([H])C(C)(C)C[C@]2([H])C1=C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liao YH, et al. Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J Nat Prod. 1999;62(9):1241-1245.  [Content Brief]

  [2]. Houghton PJ, et al. Terpenoids in Buddleja: relevance to chemosystematics, chemical ecology and biological activity. Phytochemistry. 2003;64(2):385-393.  [Content Brief]

  [3]. Takashi Yoshida, et al. Buddledin A, B and C, piscicidal sesquiterpenes from Buddleja davidi[CITATION]Franch. Tetrahedron Letters No. 41, pp 3717-3720, 1976. Pergamon Press.
  Printed in Great Britain.