2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-N15110
    Phosmidosine
    		Inhibitor
    Phosmidosine can inhibit the cell cycle progression and cell morphology recovery of srcts-NRK cells. Phosmidosine A has antifungal effects.
    Phosmidosine
  • HY-162488
    Laccase-IN-3
    		Inhibitor
    Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS.
    Laccase-IN-3
  • HY-W714655
    Becliconazole
    		Inhibitor
    Becliconazole is a fungal CYP51A1 inhibitor. Becliconazole can be used in research on fungal infections.
    Becliconazole
  • HY-178162
    CYP51-IN-27
    		Inhibitor
    CYP51-IN-27 is a sterol 14α-demethylase CYP51 inhibitor with an IC50 of 0.3434 μg/mL. CYP51-IN-27 exhibits antifungal activity and inhibits the production of fungal ergosterol. CYP51-IN-27 can be used for the research of infection, such as rice sheath blight.
    CYP51-IN-27
  • HY-N13200
    Cranberry Extract
    		Inhibitor
    Cranberry Extract is the extract of Cranberry, with content of 25% -50% Proanthocyanidins. Cranberry Extract exhibits anti-virus and antimicrbiol activity. Cranberry Extract suppresses fungal growth and biofilm formation. Cranberry Extract reduces NF-κB p65 phosphorylation, and PI3K/AKT signaling; increases caspase-8/9 activity to induce apoptosis, modulates oxidative stress, inflammation, and lipid profiles. Cranberry Extract exerts antiproliferative effects and induces cell cycle arrest. Cranberry Extract can be used for the research of infection and cancers.
    Cranberry Extract
  • HY-169856
    Pradimicin L
    		Inhibitor
    Pradimicin L is a homologue of pradimicin A (HY-132191) that can be isolated from the new type of Streptomyces madurensis, and it has antifungal activity.
    Pradimicin L
  • HY-117089R
    Tetraconazole (Standard)
    		Inhibitor
    Tetraconazole (Standard) is the analytical standard of Tetraconazole. This product is intended for research and analytical applications. Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields. Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds.
    Tetraconazole (Standard)
  • HY-N13962
    Bagremycin A
    		Inhibitor
    Bagremycin A is found in the strain of Streptomyce sp. Tu 4128. Bagremycin A has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans.
    Bagremycin A
  • HY-101506R
    2,4,6-Tribromophenyl caproate (Standard)
    		Inhibitor
    2,4,6-Tribromophenyl caproate (Standard) is the analytical standard of 2,4,6-Tribromophenyl caproate (HY-101506). This product is intended for research and analytical applications. 2,4,6-Tribromophenyl caproate (2,4,6-tribromophenyl caproic acid ester) is an anti-fungal agent.
    2,4,6-Tribromophenyl caproate (Standard)
  • HY-14272R
    Ravuconazole (Standard)
    		Inhibitor
    Ravuconazole (Standard) is the analytical standard of Ravuconazole. This product is intended for research and analytical applications. Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.
    Ravuconazole (Standard)
  • HY-N14443
    Haliangicin C
    		Inhibitor
    Haliangicin C has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin C
  • HY-N14585
    Ramulosin
    		Inhibitor
    Ramulosin has an antifungal effect and inhibits the germination of fungal meristems.
    Ramulosin
  • HY-173452
    DT-23
    		Inhibitor
    DT-23 is a potent antifungal agent with an MIC50 of 15 μg/mL. DT-23 inhibits recombinant Arg1 and Kcs1 with IC50s of 0.6 and 0.68 μM, respectively.
    DT-23
  • HY-N14995
    Frenolicin
    		Inhibitor
    Frenolicin is an antibiotic with antibacterial activity. Frenolicin also exhibits cytotoxicity against tumor cells.
    Frenolicin
  • HY-N15082
    Hypnophilin
    		Inhibitor
    Hypnophilin has a variety of activities, including anti-Gram-positive bacteria, negative bacteria, yeast, mold and tumor activities.
    Hypnophilin
  • HY-N14799
    Mycobacillin
    		Inhibitor
    Mycobacillin is a peptide antibiotic with anti-antifungal activity.
    Mycobacillin
  • HY-108547R
    Alexidine dihydrochloride (Standard)
    		Inhibitor
    Alexidine (dihydrochloride) (Standard) is the analytical standard of Alexidine (dihydrochloride). This product is intended for research and analytical applications. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens.
    Alexidine dihydrochloride (Standard)
  • HY-N13906
    Alliacol B
    		Inhibitor
    Alliacol B is an antibiotic shows weak antibacterial and antifungal activity. Alliacol B inhibits DNA synthesis in cells of the ascitic form of Ehrlich carcinoma.
    Alliacol B
  • HY-B1838A
    Asulam potassium
    		Inhibitor
    Asulam (potassium salt) is a chitin synthase inhibitor against plant pathogenic fungi. Asulam (potassium salt) interferes with the biosynthesis of chitin in the fungal cell wall to destroy the integrity and normal growth and reproduction of fungal cells, thereby exerting bacteriostatic activity. Asulam (potassium salt) is promising for research of fungal diseases such as downy mildew and gray mold in spinach, tulips, daffodils and lilies.
    Asulam potassium
  • HY-157218
    PPm
    		Inhibitor
    PPm, a derivative of penthiopyrad and hapten, is a representative member of the succinate dehydrogenase inhibitors group of fungicides.
    PPm
Cat. No. 상품명 / Synonyms Application Reactivity