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Cat. No.: HY-B1838A

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Asulam potassium

Name: Asulam potassium
Brand: MedChemExpress
SKU: HY-B1838A
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Asulam potassium is a sulfonamide Herbicide, Antibacterial agent, and DHPS inhibitor. Asulam potassium targets the folate biosynthesis pathway. Asulam potassium inhibits photosynthesis and ATP production, while inducing alterations in amino acid metabolism, mitotic spindle disruption leading to metaphase arrest, and chromosome aberration induction. Asulam potassium impedes the growth of transformed root species. Asulam potassium has activity against Arabidopsis thaliana and Escherichia coli.

For research use only. We do not sell to patients.

CAS No.: 14089-43-1
Formula: C₈H₁₀KN₂O₄S
Molecular Weight:269.34

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Asulam potassium Chemical Structure

CAS No.: 14089-43-1

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Biological Activity
- Description
- In Vitro
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Publications (1)
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Biological Activity

Description

All Folate Receptor (FR) Isoforms :

FR-α

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Asulam (0.04-2 mM; 20 h) exhibits weak antibacterial activity against E. coli and is ineffective against B. subtilis within the tested concentration range^[1].
Asulam (0.125-4 mM; 15 days) is the most effective of the tested sulfonamide herbicides against Arabidopsis thaliana, inhibiting growth from 0.25 mM onward after pre-emergence application^[1].

Others

Asulam (200 μM) binds to EcDHPS, confirming its interaction with the target protein of sulfonamide antibiotics^[3].
Asulam (100 μg/mL) selects for Sulfamethoxazole (HY-B0322)-tolerant Escherichia coli BW25113 in vitro by increasing the frequency of chromosomal folP mutations^[3].
Asulam (1.1 kg ae/ha; 6 days) does not significantly affect the chlorophyll content of wild oat (Avena fatua L.) leaves 6 days after foliar application at 1.1 kg/ha^[4].
Asulam (1.1 kg ae/ha; 6 days) inhibits ATP production by 35% in wild oat (Avena fatua L.) leaves 6 days after foliar application of 1.1 kg/ha^[4].
Asulam inhibits the growth of Cirsium cell suspension cultures but does not cause a significant loss of cell viability as determined by fluorescein diacetate staining^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 14089-43-1
Molecular Weight 269.34
Formula C₈H₁₀KN₂O₄S
SMILES

O=C(NS(=O)(C1=CC=C(C=C1)N)=O)OC.[K]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Molecules

Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]

2025 Mar 9;30(6):1224. PMID: 40142001

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vadlamani G, et al. Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam. Plant communications. 2022 Jul 11;3(4):100322.

[2]. Mugnier J. Behaviour of Herbicides in Dicotyledonous Roots Transformed by Agrobacterium rhizogenes: I. SELECTIVITY[J]. Journal of experimental botany, 1988, 39(8): 1045-1056.

[3]. Muntz L P. Herbicide Mediated Selection of Sulfonamide Resistant E. coli[D]. The University of Western Ontario (Canada), 2022.

[4]. Chow P N P. Wild oat (Avena fatua) herbicide studies: I. Physiological response of wild oat to five postemergence herbicides[J]. Weed Science, 1982, 30(1): 1-6.

[5]. Gressel J. In vitro plant cultures for herbicide prescreening[J]. 1987.

[6]. NICKELL L G. Chemical enhancement of sucrose accumulation in sugarcane[J]. 1977.

[7]. Sterrett R B, et al. Asulam-induced Mitotic Irregularities in Onion Root-tips1[J]. Hortscience, 1975, 10(2): 161-162.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Asulam potassium

1 Cited Publications

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Biological Activity
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Chemical Information
Publications (1)
Purity & Documentation
References

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Asulam potassium

Publications Citing Use of MedChemExpress (MCE) Asulam potassium

All Folate Receptor (FR) Isoforms