2. Anti-infection NF-κB Apoptosis PI3K/Akt/mTOR
  3. Bacterial NF-κB Caspase Apoptosis PI3K Akt Fungal
  4. Cranberry Extract

Cranberry Extract is the extract of Cranberry, with content of 25% -50% Proanthocyanidins. Cranberry Extract exhibits anti-virus and antimicrbiol activity. Cranberry Extract suppresses fungal growth and biofilm formation. Cranberry Extract reduces NF-κB p65 phosphorylation, and PI3K/AKT signaling; increases caspase-8/9 activity to induce apoptosis, modulates oxidative stress, inflammation, and lipid profiles. Cranberry Extract exerts antiproliferative effects and induces cell cycle arrest. Cranberry Extract can be used for the research of infection and cancers.

For research use only. We do not sell to patients.

Cranberry Extract

Cranberry Extract Chemical Structure

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Cranberry Extract Related Antibodies

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

  • Biological Activity

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Description

Cranberry Extract is the extract of Cranberry, with content of 25% -50% Proanthocyanidins. Cranberry Extract exhibits anti-virus and antimicrbiol activity. Cranberry Extract suppresses fungal growth and biofilm formation. Cranberry Extract reduces NF-κB p65 phosphorylation, and PI3K/AKT signaling; increases caspase-8/9 activity to induce apoptosis, modulates oxidative stress, inflammation, and lipid profiles. Cranberry Extract exerts antiproliferative effects and induces cell cycle arrest. Cranberry Extract can be used for the research of infection and cancers[1][2][3][5][6].

In Vitro

Cranberry extract suppresses cariogenic pathogenicity features of Streptococcus mutans and Candida albicans dual-species biofilms[1].
Cranberry extract (20 h) protects HepG2 liver cells from t-BOOH-induced oxidative stress by reducing antioxidant enzyme over-activation, MDA levels, and modulating cell signaling pathways[1].
Cranberry extract reduces pro-inflammatory mediator production and NF-κB activation in pre-incubated Caco-2/15 intestinal cells[1].
Cranberry extract exerts anti-proliferative activity against KB nasopharyngeal carcinoma cells, but not against AW13516 tongue squamous cell carcinoma cells[1].
Cranberry extract induces apoptosis in DU145 human prostate adenocarcinoma cells by increasing caspase-8 and caspase-9 activities[1].
Cranberry extract (200 µg/mL; 48 h) exhibits selective antiproliferative activity against human KB, HT-29, HCT116, SW620, RWPE-1, RWPE-2, and 22Rv1 cancer cell lines[2].
Cranberry Extract inhibits growth of vancomycin-resistant Enterococcus faecium, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli[4].
Cranberry extract (0.0050-0.10% (v/v); 4 h) significantly inhibits cupric sulfate-induced TBARS formation in isolated human LDL[6].
Cranberry extract (0.0050-0.10% (v/v); 4 h) significantly reduces cupric sulfate-induced relative electrophoretic mobility of isolated human LDL[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cranberry Extract Related Antibodies

Cell Viability Assay[2]

Cell Line: KB, CAL27, HT-29, HCT116, SW480, SW620, RWPE-1, RWPE-2, 22Rv1
Concentration: 200 µg/mL
Incubation Time: 48 h
Result: Inhibited proliferation of KB oral cancer cells by 60%.
Inhibited proliferation of CAL27 oral cancer cells by 8%.
Inhibited proliferation of HT-29 colon cancer cells by 78%.
Inhibited proliferation of HCT116 colon cancer cells by 56%.
Inhibited proliferation of SW620 colon cancer cells by 35%.
Showed no inhibition of SW480 colon cancer cells.
Inhibited proliferation of 22Rv1 prostate cancer cells by 85%.
Inhibited proliferation of RWPE-1 prostate cancer cells by 65%.
Inhibited proliferation of RWPE-2 prostate cancer cells by 65%.
Clinical Trial
Appearance

Solid

Color

Orange to reddish brown

SMILES

[Cranberry Extract]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Purity & Documentation
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Cranberry Extract Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cranberry ExtractBacterialNF-κBCaspaseApoptosisPI3KAktFungalNuclear factor-κBNuclear factor-kappaBPhosphoinositide 3-kinasePKBProtein kinase Bneuraminidasecaspase-8pancreatic lipaseNF-κB p65proline dehydrogenaseureasePI3K/AKT signalingfructosyl transferaseglucosyl transferasecyclooxygenaseInhibitorinhibitorinhibit

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