Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (2612)
Antibodies (1)
Related Compound Screening Libraries (1)

By Effects:	Inhibitors (2326) Controls (5) Ligand (1) Antagonists (2) Activators (2) Modulators (2) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-139161

Penflufen	Inhibitor	99.81%
Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases.

HY-10219GL

Rapamycin (GMP Like)	Inhibitor
Rapamycin (Sirolimus) GMP Like is Rapamycin (HY-10219) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

HY-Y0248AS

(E,E)-Farnesol-d₆		98.71%
(E,E)-Farnesol-d₆ (trans,trans-Farnesol-d₆) is deuterium labeled (E,E)-Farnesol (HY-Y0248). (E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness.

HY-P2292

Omiganan, FITC labeled	Inhibitor	98.20%
Omiganan, FITC labeled is a peptide-FITC complex composed of Omiganan and a FITC. Omiganan is a bactericidal and fungicidal cationic peptide being developed as a topical gel for prevention of catheter-associated infections. FITC is a derivative of fluorescein for the labeling of amines.

HY-N0414R

Trigonelline (Standard)	Inhibitor
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-130802

5-Aminouridine	Inhibitor	99.31%
5-Aminouridine can modify nucleobases and can be incorporated into the target DNA. 5-Aminouridine exhibits a wide range of biological activity and it inhibits the growth of tumors, fungi and viruses.

HY-17373R

Posaconazole (Standard)	Inhibitor
Posaconazole (Standard) is the analytical standard of Posaconazole. This product is intended for research and analytical applications. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.

HY-16779B

Fosravuconazole L-lysine ethanolate	Inhibitor	99.86%
Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a proagent of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used for candidiasis, onychomycosis and parasitemia research.

HY-B0370R

Tolnaftate (Standard)	Inhibitor
Tolnaftate (Standard) is the analytical standard of Tolnaftate. This product is intended for research and analytical applications. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .

HY-B1224

Exalamide	Inhibitor	99.99%
Exalamide (2-(Hexyloxy)benzamide), an arenecarboxamide, is a potent antifungal agent.

HY-109040

Quilseconazole	Inhibitor	98.61%
Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases.

HY-125776

Kresoxim-methyl	Inhibitor	99.83%
Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent K_d of 0.07 μM proving a high affinity for this enzyme.

HY-N10113

Verrucarin J	Inhibitor	99.9%
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC₅₀ of 1.2 ng/mL.

HY-119663

Averantin	Inhibitor	99.90%
Averantin is the minor metabolite of the fungus Cercospora arachidicola. Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway.

HY-U00058

Diflucortolone valerate	Inhibitor	99.48%
Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases.

HY-N3570

Cerebroside B	Inhibitor	98%
Cerebroside B, a sphingolipid compound, is a non-racespecific elicitor, which elicits defense responses in rice.

HY-E70250

Neocryptolepine	Inhibitor	98.05%
Neocryptolepine (Cryptotackieine) has antiplasmodial activity. Neocryptolepine also shows antibacterial activity against Gram-positive bacteria (MIC < 100 μg/mL), and antifungal activity.

HY-N3270

Methyl orsellinate	Inhibitor	99.91%
Methyl orsellinate is a phytotoxic compound with antifungal activities. Methyl orsellinate is a 5-lipoxygenase inhibitor with an IC₅₀ value of 59.6 μM. Methyl orsellinate can be used for fungal infection research.

HY-B1852

Sulfometuron-methyl	Inhibitor
Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III.

HY-163459

HWY-289	Inhibitor	98.0%
HWY-289 is a semisynthetic protoberberine derivative, has broad-spectrum and potent activities against phytopathogenic fungi, particularly Botrytis cinerea (EC₅₀ = 1.34 μg/mL). HWY-289 changes the morphology of the mycelium and the internal structure of cells. HWY-289 reduces ATP content, ATPase activities, and key enzyme activities in the TCA cycle.

Antifungal Compound Library

Compound library containing all kinds of molecules with anti-fungal activity.

559compounds HY-L048

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Fungal

Fungal

Fungal Related Products (2612)

Antibodies (1)

Related Compound Screening Libraries (1)

Fungal Related Products (2612):