5-Aminouridine
Based on 1 Customer Validation
5-Aminouridine can modify nucleobases and can be incorporated into the target DNA. 5-Aminouridine exhibits a wide range of biological activity and it inhibits the growth of tumors, fungi and viruses.
For research use only. We do not sell to patients.
- Purity: 99.31%
- CAS No.: 2149-76-0
- Formula: C9H13N3O6
- Molecular Weight:259.22
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
The modified nucleobase, 5-Aminouridine, must exhibit a low enough potential to be oxidized by Os(bpy)33+. 5-Aminouridine can be inserted into the target DNA by direct synthesis using modified phosphoramidites[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2149-76-0
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Appearance Solid
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Molecular Weight 259.22
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Formula C9H13N3O6
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Color Off-white to light yellow
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SMILES
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N(C(N2)=O)C=C(N)C2=O)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 25 mg/mL (96.44 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Smith DA, et al. Studies on 5-aminouridine. Biochim Biophys Acta. 1966 May 19;119(2):221-8. [Content Brief]
[2]. ROBERTS M, et al. Antimetabolite activity of uridine and cytidine derivatives. J Biol Chem. 1952 Feb;194(2):695-701. PMID: 14927662.. . . [Content Brief]
[3]. MR, et al. Detection of attomole quantities [correction of quantitites] of DNA targets on gold microelectrodes by electrocatalytic nucleobase oxidation. Anal Chem. 2003 Dec 1;75(23):6586-92. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.8577 mL | 19.2886 mL | 38.5773 mL | 96.4432 mL |
| 5 mM | 0.7715 mL | 3.8577 mL | 7.7155 mL | 19.2886 mL | |
| 10 mM | 0.3858 mL | 1.9289 mL | 3.8577 mL | 9.6443 mL | |
| 15 mM | 0.2572 mL | 1.2859 mL | 2.5718 mL | 6.4295 mL | |
| 20 mM | 0.1929 mL | 0.9644 mL | 1.9289 mL | 4.8222 mL | |
| 25 mM | 0.1543 mL | 0.7715 mL | 1.5431 mL | 3.8577 mL | |
| 30 mM | 0.1286 mL | 0.6430 mL | 1.2859 mL | 3.2148 mL | |
| 40 mM | 0.0964 mL | 0.4822 mL | 0.9644 mL | 2.4111 mL | |
| 50 mM | 0.0772 mL | 0.3858 mL | 0.7715 mL | 1.9289 mL | |
| 60 mM | 0.0643 mL | 0.3215 mL | 0.6430 mL | 1.6074 mL | |
| 80 mM | 0.0482 mL | 0.2411 mL | 0.4822 mL | 1.2055 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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