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  3. Fosravuconazole L-lysine ethanolate

Fosravuconazole L-lysine ethanolate (Synonyms: BMS-379224 L-lysine ethanolate; E-1224 L-lysine ethanolate)

Cat. No.: HY-16779B Purity: 96.30%
Handling Instructions

Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a prodrug of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used for candidiasis, onychomycosis and parasitemia research.

For research use only. We do not sell to patients.

Fosravuconazole L-lysine ethanolate Chemical Structure

Fosravuconazole L-lysine ethanolate Chemical Structure

CAS No. : 914361-45-8

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5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1550 In-stock
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100 mg USD 2350 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a prodrug of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used for candidiasis, onychomycosis and parasitemia research[1][2][3].

In Vitro

Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida, Aspergillus, and Trichophyton species[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain)[3].
Dosage: 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg
Administration: Oral administration; daily; for 20 days
Result: Suppressed the parasitemia and prevented death.
Clinical Trial
Molecular Weight

739.73

Formula

C₃₁H₄₀F₂N₇O₈PS

CAS No.
SMILES

N#CC1=CC=C(C2=CSC([[email protected]](C)[[email protected]@](OCOP(O)(O)=O)(C3=CC=C(F)C=C3F)CN4N=CN=C4)=N2)C=C1.CCO.N[[email protected]](C(O)=O)CCCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (67.59 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3518 mL 6.7592 mL 13.5184 mL
5 mM 0.2704 mL 1.3518 mL 2.7037 mL
10 mM 0.1352 mL 0.6759 mL 1.3518 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Fosravuconazole L-lysine ethanolateBMS-379224 L-lysine ethanolateE-1224 L-lysine ethanolateFungalParasiteRavuconazoleantifungalonychomycosisparasitemiacandidiasisInhibitorinhibitorinhibit

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Product Name:
Fosravuconazole L-lysine ethanolate
Cat. No.:
HY-16779B
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