1. Anti-infection
  2. Fungal
    Parasite
  3. Fosravuconazole

Fosravuconazole (Synonyms: BMS-379224; E-1224)

Cat. No.: HY-16779 Purity: 98.48%
Handling Instructions

Fosravuconazole (BMS-379224), a prodrug of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole can be used for candidiasis, onychomycosis and parasitemia research.

For research use only. We do not sell to patients.

Fosravuconazole Chemical Structure

Fosravuconazole Chemical Structure

CAS No. : 351227-64-0

Size Price Stock Quantity
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 390 In-stock
Estimated Time of Arrival: December 31
25 mg USD 780 Get quote
50 mg USD 1250 Get quote
100 mg USD 1950 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Fosravuconazole:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fosravuconazole (BMS-379224), a prodrug of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole can be used for candidiasis, onychomycosis and parasitemia research[1][2][3].

IC50 & Target

Fungal[1]

In Vitro

Ravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida, Aspergillus, and Trichophyton species[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain)[3].
Dosage: 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg
Administration: Oral administration; daily; for 20 days
Result: Suppressed the parasitemia and prevented death.
Clinical Trial
Molecular Weight

547.47

Formula

C23H20F2N5O5PS

CAS No.
SMILES

N#CC1=CC=C(C2=CSC([[email protected]](C)[[email protected]@](OCOP(O)(O)=O)(C3=CC=C(F)C=C3F)CN4N=CN=C4)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (182.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8266 mL 9.1329 mL 18.2658 mL
5 mM 0.3653 mL 1.8266 mL 3.6532 mL
10 mM 0.1827 mL 0.9133 mL 1.8266 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Fosravuconazole
Cat. No.:
HY-16779
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