2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156241
    Meliadubin B
    		Inhibitor
    Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC50 of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC50 of 182.50 μM.
    Meliadubin B
  • HY-N12264
    Burnettramic acid A
    		Inhibitor
    Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC50 of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candida albicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC50 of 13.8 μg/mL.
    Burnettramic acid A
  • HY-142914
    Antifungal agent 21
    Antifungal agent 21 is a promising candidate in the development of new agrochemical antifungal agents.
    Antifungal agent 21
  • HY-W272811
    Camphorsulfonate sodium
    		Inhibitor
    Camphorsulfonate sodium is an organic synthesis intermediate. Camphorsulfonate sodium can be used for synthesis of derivatives with SDH inhibitory activity through scaffold hopping. Camphorsulfonate sodium is also an organocatalyst that can be used as a pore-forming additive for modulating the porosity of the graphene film. Camphorsulfonate sodium can be used for binder-free porous graphene film and fungicide research.
    Camphorsulfonate sodium
  • HY-W010649R
    Isoxazole (Standard)
    		Inhibitor
    Amfenac (Sodium Hydrate) (Standard) is the analytical standard of Amfenac (Sodium Hydrate). This product is intended for research and analytical applications. Amfenac Sodium Hydrate is a COX-2 inhibitor.
    Isoxazole (Standard)
  • HY-N0709S1
    Coumarin-d6
    		Inhibitor
    Coumarin-d6 is deuterated labeled Coumarin (HY-N0709). Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity.
    Coumarin-d<sub>6</sub>
  • HY-163437
    Antitubercular agent-45
    		Inhibitor
    Antitubercular agent-45 (Compound 5g) is an antifungal and antitubercular agent. Antitubercular agent-45 inhibits S. aureus, MRSA, B. subtilis, E. coli, C. albicans with MIC values of 6.4, 10.8, 6.1, 8.4 , 8.1 μM respectively.
    Antitubercular agent-45
  • HY-172810
    Succinate dehydrogenase-IN-8
    		Inhibitor
    Succinate dehydrogenase-IN-8 (compound i19) is a potent succinate dehydrogenase (SDH) inhibitor. Succinate dehydrogenase-IN-8, an indene amino acid derivative, demonstrates potent in vitro antifungal activity against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L).
    Succinate dehydrogenase-IN-8
  • HY-B0221A
    Amphotericin B trihydrate
    		Inhibitor
    Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity.
    Amphotericin B trihydrate
  • HY-113799
    Echinosporin
    Echinosporin (XK-213) is an antibiotic. Echinosporin can be isolated from Amycolatopsis strain. Echinosporin has antifungal activity and antitumor activity.
    Echinosporin
  • HY-P11021
    ToAP2
    		Inhibitor
    ToAP2 is a potent antimicrobial peptide. ToAP2 affects C. albicans membrane permeability and produces changes in fungal cell morphology.
    ToAP2
  • HY-155084
    Antifungal agent 61
    		Inhibitor
    Antifungal agent 61 (Compound 38) is an antifungal agent. Antifungal agent 61 inhibits V. mali with an EC50 value of 0.50 mg/L. Antifungal agent 61 inhibits V. mali by causing cell deformation and contraction, reducing the number of intracellular mitochondria, thickening the cell wall, and increasing the permeability of the cell membrane.
    Antifungal agent 61
  • HY-N12106
    Neosartoricin
    Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri. Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC50 of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence.
    Neosartoricin
  • HY-B0364AS
    Dyclonine-d9 hydrochloride
    		Inhibitor
    Dyclonine-d9 (hydrochloride) is deuterium labeled Dyclonine (hydrochloride). Dyclonine hydrochloride (Dyclocaine hydrochloride) is an effective component of Runhou tablets. Dyclonine hydrochloride has significant bactericidal and fungicidal activity.
    Dyclonine-d<sub>9</sub> hydrochloride
  • HY-161375
    SDH-IN-13
    		Inhibitor
    SDH-IN-13 (Compound 5IIIh) is a SDH inhibitor (IC50: 13.7 μg/mL) and an antifungal agent.
    SDH-IN-13
  • HY-162500
    Antifungal agent 99
    		Inhibitor
    Antifungal agent 99 (Compound E1) is a fungal succinate dehydrogenase (SDH) inhibitor. Antifungal agent 99 reduces mycelial density and significantly increase the mitochondrial number in mycelia cytoplasm.
    Antifungal agent 99
  • HY-N14363
    Fistupyrone
    		Inhibitor
    Fistupyrone, an antibiotic, is a microbial metabolite found in Streptomyces sp. TP-A0569. Fistupyrone inhibits Alternaria brassicicola infected Chinese cabbage.
    Fistupyrone
  • HY-176964
    N-Choloylphenylalanine
    N-Choloylphenylalanine (Compound 6273) (PheCA) is a VPR-induced growth arrest inhibitor. N-Choloylphenylalanine alleviates VPR-induced growth arrest. N-Choloylphenylalanine can be used in yeast and HIV-1 infection research.
    N-Choloylphenylalanine
  • HY-W010203S1
    2-Decanone-d5-1
    2-Decanone-d5-1 is the deuterium labeled 2-Decanone (HY-W010203). 2-Decanone is an antifungal agent. 2-Decanone inhibits pathogen mycelial growth, spore germination, and appressorium formation. 2-Decanone downregulates spore germination-related genes (MfBmp1) and penetration structure formation genes (MfPls1), inducing reactive oxygen species (ROS) accumulation to trigger mitochondrial damage and subsequent spore apoptosis. 2-Decanone is promising for research of postharvest disease control in fruits and vegetables.
    2-Decanone-d<sub>5</sub>-1
  • HY-163353
    Antibacterial agent 193
    		Inhibitor
    Antibacterial agent 193 (Compound 2n) is A monobenzene derivative of spiromarone A, which has antibacterial activity against Rhizoctonia solani. with IC50 value of 5.25 μg/mL.
    Antibacterial agent 193
Cat. No. Product Name / Synonyms Application Reactivity