Amphotericin B trihydrate
Based on 31 publication(s) in Google Scholar
Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity.
For research use only. We do not sell to patients.
- CAS No.: 1202017-46-6
- Formula: C47H79NO20
- Molecular Weight:978.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Amphotericin B trihydrate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Cell. 2022 Aug 18;185(17):3124-3137.e15. [Abstract]
- Cell Host Microbe. 2026 Jul 8;34(7):1350-1366.e8. [Abstract]
- J Adv Res. 2026 Apr 13:S2090-1232(26)00337-1. [Abstract]
- J Nanobiotechnology. 2024 Jun 19;22(1):345. [Abstract]
- Environ Sci Technol. 2026 Apr 14;60(14):10525-10537. [Abstract]
- Adv Biotechnol (Singap). 2025 Mar 11;3(1):8. [Abstract]
- Antioxidants (Basel). 2025 Aug 25;14(9):1046. [Abstract]
- Virulence. 2026 Dec;17(1):2629100. [Abstract]
- J Agric Food Chem. 2026 Jun 3;74(21):16299-16311. [Abstract]
- Front Cell Infect Microbiol. 2020 Jun 26;10:320. [Abstract]
- Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C277-C286. [Abstract]
- Probiotics Antimicrob Proteins. 2026 Jan 6. [Abstract]
- Molecules. 2020 Apr 23;25(8):1980. [Abstract]
- Cancers (Basel). 2022 Jul 21;14(14):3550. [Abstract]
- Neuropharmacology. 2019 Jun:151:33-44. [Abstract]
- Microbiol Spectr. 2025 Mar 31:e0318524. [Abstract]
- Microbiol Spectr. 2023 Jun 15;11(3):e0530222. [Abstract]
- J Virol. 2020 Nov 23;94(24):e01350-20. [Abstract]
- Infect Drug Resist. 2022 Dec 15:15:7459-7473. [Abstract]
- PeerJ. 2025 Jun 16:13:e19544. [Abstract]
- Toxicon. 2024 Jun 5:246:107795. [Abstract]
- J Appl Microbiol. 2021 Apr;130(4):1154-1172. [Abstract]
- J Mol Histol. 2026 Jun 25;57(4):206. [Abstract]
- J Mol Histol. 2026 Jan 12;57(1):43. [Abstract]
- J Mycol Med. 2022 Mar;32(1):101227. [Abstract]
- Phytochem Lett. 2023 Aug, 56, 24-29.
- University of Szeged. 2026.
- Patent. US20250235403A1.
- Patent. US20240417738A1.
- Evid Based Complement Alternat Med. 2015:2015:639412. [Abstract]
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In Vivo Efficacy Study
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Biological Activity
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Leishmania |
Plasmodium |
Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase[4]. Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K+ leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na+ entry into the cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1202017-46-6
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Molecular Weight 978.12
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Formula C47H79NO20
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SMILES
C[C@H]([C@@H](O)[C@@H](C)[C@H](C)OC1=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@]2([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1)(O)O3.[H]O[H].[H]O[H].[H]O[H]
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Structure Classification
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Initial Source
actinomycete Streptomyces nodosus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (31)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Cell
2022 Aug 18;185(17):3124-3137.e15. PMID: 35944541 -
Cell Host Microbe
Gut bacteria that produce fatty acid ethanolamides alleviate diarrhea-predominant IBS with insulin resistance. [Abstract]2026 Jul 8;34(7):1350-1366.e8. PMID: 42320473 -
J Adv Res
Portulaca oleracea L. polysaccharide alleviates colitis-associated bone loss through Muribaculaceae-enriched gut microbiota and elevated colonic melatonin. [Abstract]2026 Apr 13:S2090-1232(26)00337-1. PMID: 41980626 -
J Nanobiotechnology
Cartilage progenitor cells derived extracellular vesicles-based cell-free strategy for osteoarthritis treatment by efficient inflammation inhibition and extracellular matrix homeostasis restoration. [Abstract]2024 Jun 19;22(1):345. PMID: 38890638 -
Environ Sci Technol
Aquatic Toxicological Assessment of Solid Pyrolysis Product (SPP) from Synthetic Textile Feedstock Relative to Biochar, Carbon Black, and Activated Carbon. [Abstract]2026 Apr 14;60(14):10525-10537. PMID: 41931823 -
Adv Biotechnol (Singap)
Simplifying the protocol for low-pollution-risk, efficient mouse myoblast isolation and differentiation. [Abstract]2025 Mar 11;3(1):8. PMID: 40067554 -
Antioxidants (Basel)
Hyssopus cuspidatus Boriss Volatile Extract (SXC): A Dual-Action Antioxidant and Antifungal Agent Targeting Candida albicans Pathogenicity and Vulvovaginal Candidiasis via Host Oxidative Stress Modulation and Fungal Metabolic Reprogramming. [Abstract]2025 Aug 25;14(9):1046. PMID: 41008953
Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2025 Aug 25;14(9):1046. [Abstract]
Time–kill curves of C. albicans strains treated with AmB (MIC: 0.0625 μg/mL)-SXC and FLC-SXC combinations at fractional inhibitory concentration index (FICI) concentrations(Amphotericin B: AmB).
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Virulence
The cyclin dependent kinase (CDK)7 inhibitor BS-181 inhibits pathogenic Cryptococcus species, causing G2/M arrest and a splicing defect. [Abstract]2026 Dec;17(1):2629100. PMID: 41701636 -
J Agric Food Chem
Resveratrol Analog ResA1 Targeting MoYpk1 Exhibits Broad-Spectrum Antifungal Activity against Rice Blast. [Abstract]2026 Jun 3;74(21):16299-16311. PMID: 42172023 -
Front Cell Infect Microbiol
Caenorhabditis elegans- Based Aspergillus fumigatus Infection Model for Evaluating Pathogenicity and Drug Efficacy. [Abstract]2020 Jun 26;10:320. PMID: 32670897
Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Front Cell Infect Microbiol. 2020 Jun 26;10:320. [Abstract]
Kaplan-Meier survival plots of C. elegans infected by KU80△ in the presence of antifungal drugs. The glp-4(bn2); sek-1(km4) worms were pre-infected with KU80△ for 8 h then transferred into liquid killing media containing different concentrations of Amphotericin B (1-2 μg/mL; 0-72 h).
Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Front Cell Infect Microbiol. 2020 Jun 26;10:320. [Abstract]
Effect of antifungal treatment on Af293-dsRed infection to glp-4(bn2); sek-1(km4) worms. Images were taken under DIC and TRITC channels from DMSO treatment by 24 h, 1.5 μg/mL Amphotericin B (AmB) treatment by 48 h. Scale bar is 200 μm.
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Am J Physiol Cell Physiol
Electrical stimulation facilitates the angiogenesis of human umbilical vein endothelial cells through MAPK/ERK signaling pathway by stimulating FGF2 secretion. [Abstract]2019 Aug 1;317(2):C277-C286. PMID: 30995109 -
Probiotics Antimicrob Proteins
Screening the γ-core Motif Peptides of Ascomycetous Antifungal Proteins for Antifungal Activity and Potential Therapeutic Applicability. [Abstract]2026 Jan 6. PMID: 41493708 -
Molecules
In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei. [Abstract]2020 Apr 23;25(8):1980. PMID: 32340370 -
Cancers (Basel)
Pulmonary Delivery of Extracellular Vesicle-Encapsulated Dinaciclib as an Effective Lung Cancer Therapy. [Abstract]2022 Jul 21;14(14):3550. PMID: 35884614 -
Neuropharmacology
Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome. [Abstract]2019 Jun:151:33-44. PMID: 30954529 -
Microbiol Spectr
Synergistic antifungal activity of minocycline as an effective augmenting agent of fluconazole against drug-resistant Candida tropicalis. [Abstract]2025 Mar 31:e0318524. PMID: 40162832 -
Microbiol Spectr
In Vitro and In Vivo Evaluation of Synergistic Effects of Everolimus in Combination with Antifungal Agents on Exophiala dermatitidis. [Abstract]2023 Jun 15;11(3):e0530222. PMID: 37140396
Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2023 Jun 15;11(3):e0530222. [Abstract]
Changes in ROS generation ratio in Amphotericin B (1 μg/mL; 90 min) group. In flow cytometry analysis, the abscissa represents the relative fluorescence intensity, and the ordinate represents the spore count. The dark blue area represents the percentage of spores (P3) with emitted fluorescence after DHR-123 was oxidized. The peak value in the dark blue area indicates the largest number of oxidized spores under the corresponding fluorescence intensity.
Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2023 Jun 15;11(3):e0530222. [Abstract]
Survival rates in mono-treatment and combination treatment groups. Note: The survival curves of larvae infected with E. dermatitidis after different interventions. Amphotericin B (AMB) (1 μg/mL) or AMB (0.25 μg/mL) combine with EVL can significantly improve the survival rate of larvae for 6 days.
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J Virol
Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion. [Abstract]2020 Nov 23;94(24):e01350-20. PMID: 32999030 -
Infect Drug Resist
Correlation Between Drug Resistance and Virulence of Candida Isolates from Patients with Candidiasis. [Abstract]2022 Dec 15:15:7459-7473. PMID: 36544991 -
PeerJ
Antifungal effects of andrographolide and its combination with amphotericin B against selected fungal pathogens. [Abstract]2025 Jun 16:13:e19544. PMID: 40538737 -
Toxicon
Hepatoprotective effect of diammonium glycyrrhizinate and neuroprotective effect of piperazine ferulate on AmB-induced liver and kidney injury by suppressing apoptosis in vitro and in vivo. [Abstract]2024 Jun 5:246:107795. PMID: 38849008 -
J Appl Microbiol
Enhanced in vitro antimicrobial activity of amphotericin B with berberine against dual-species biofilms of Candida albicans and Staphylococcus aureus. [Abstract]2021 Apr;130(4):1154-1172. PMID: 32996236 -
J Mol Histol
Leukemia inhibitory factor drives malignant progression in lung squamous cell carcinoma via the PI3K/AKT/GSK-3β/β-catenin axis. [Abstract]2026 Jun 25;57(4):206. PMID: 42350744 -
J Mol Histol
β-Ionone inhibits A. sydowii mediated LUAD progression by inhibiting myeloid-derived suppressor cell (MDSC) expansion and activation. [Abstract]2026 Jan 12;57(1):43. PMID: 41524781 -
J Mycol Med
In vitro synergistic effect of minocycline combined with antifungals against Cryptococcus neoformans. [Abstract]2022 Mar;32(1):101227. PMID: 34800920 -
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Evid Based Complement Alternat Med
Electroacupuncture at Bilateral Zusanli Points (ST36) Protects Intestinal Mucosal Immune Barrier in Sepsis. [Abstract]2015:2015:639412. PMID: 26346309
Purity & Documentation
References
[1]. A Lemke, et al. Amphotericin B Appl Microbiol Biotechnol. 2005 Aug;68(2):151-62. [Content Brief]
[2]. Andreza Rochelle do Vale Morais, et al. In-vitro and in-vivo antileishmanial activity of inexpensive Amphotericin B formulations: Heated Amphotericin B and Amphotericin B-loaded microemulsion. Exp Parasitol. 2018 Sep;192:85-92. [Content Brief]
[3]. Ramos H, et al. Amphotericin B kills unicellular leishmanias by forming aqueous pores permeable to small cations and anions. J Membr Biol. 1996 Jul;152(1):65-75. [Content Brief]
[4]. Demaimay R, et al. Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J Gen Virol. 1994 Sep;75 (Pt 9):2499-503. [Content Brief]
[5]. Adams ML, et al. Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules. 2003 May-Jun;4(3):750-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amphotericin B trihydrate Related Classifications
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