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  4. Amphotericin B trihydrate

Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity.

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CAS No. : 1202017-46-6

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Top Publications Citing Use of Products

    Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2025 Aug 25;14(9):1046.

    Time–kill curves of C. albicans strains treated with AmB (MIC: 0.0625 μg/mL)-SXC and FLC-SXC combinations at fractional inhibitory concentration index (FICI) concentrations(Amphotericin B: AmB).

    Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2023 Jun 15;11(3):e0530222.  [Abstract]

    Changes in ROS generation ratio in Amphotericin B (1 μg/mL; 90 min) group. In flow cytometry analysis, the abscissa represents the relative fluorescence intensity, and the ordinate represents the spore count. The dark blue area represents the percentage of spores (P3) with emitted fluorescence after DHR-123 was oxidized. The peak value in the dark blue area indicates the largest number of oxidized spores under the corresponding fluorescence intensity.

    Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2023 Jun 15;11(3):e0530222.  [Abstract]

    Survival rates in mono-treatment and combination treatment groups. Note: The survival curves of larvae infected with E. dermatitidis after different interventions. Amphotericin B (AMB) (1 μg/mL) or AMB (0.25 μg/mL) combine with EVL can significantly improve the survival rate of larvae for 6 days.

    Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Front Cell Infect Microbiol. 2020 Jun 26;10:320.  [Abstract]

    Kaplan-Meier survival plots of C. elegans infected by KU80△ in the presence of antifungal drugs. The glp-4(bn2); sek-1(km4) worms were pre-infected with KU80△ for 8 h then transferred into liquid killing media containing different concentrations of Amphotericin B (1-2 μg/mL; 0-72 h).

    Amphotericin B trihydrate purchased from MedChemExpress. Usage Cited in: Front Cell Infect Microbiol. 2020 Jun 26;10:320.  [Abstract]

    Effect of antifungal treatment on Af293-dsRed infection to glp-4(bn2); sek-1(km4) worms. Images were taken under DIC and TRITC channels from DMSO treatment by 24 h, 1.5 μg/mL Amphotericin B (AmB) treatment by 48 h. Scale bar is 200 μm.

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    Description

    Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity[1][2].

    IC50 & Target

    Leishmania

     

    Plasmodium

     

    In Vitro

    Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase[4]. Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K+ leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na+ entry into the cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Amphotericin B trihydrate Related Antibodies
    In Vivo

    Amphotericin B results in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. Amphotericin B markedly reduces PrPSc levels in mice with transmissible subacute spongiform encephalopathies (TSSE)[4]. Amphotericin B exerts a direct effect on Plasmodium falciparum and influences eryptosis of infected erythrocytes, parasitemia and hostsurvival in murine malaria. Amphotericin B tends to delay the increase of parasitemia and significantly delays host death plasmodium berghei-infected mice[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    978.12

    Formula

    C47H79NO20
    CAS No.
    SMILES

    C[C@H]([C@@H](O)[C@@H](C)[C@H](C)OC1=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@]2([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1)(O)O3.[H]O[H].[H]O[H].[H]O[H]
    Structure Classification
    Initial Source

    actinomycete Streptomyces nodosus
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Amphotericin B trihydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Amphotericin B1202017-46-6AntibioticFungalBacterialParasiteInhibitorinhibitorinhibit

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