Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2737)
Related Products (2737)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Sertaconazole nitrate (Standard)
0 ImagesSynonyms: FI7056 (Standard)Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate). This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells.
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Antifungal agent 84
0 ImagesCat. No.: HY-143334CAS No.: 2901064-07-9Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability.
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Anisocoumarin H
0 ImagesCat. No.: HY-N11434CAS No.: 123237-86-5Anisocoumarin H is a coumarin that exhibits antifungal activity. Anisocoumarin H shows the activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs of 62.5 µg/mL.
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Momilactone A
0 ImagesCat. No.: HY-N11293CAS No.: 51415-07-7Momilactone A is a naturally derived diterpene lactone with multiple biological activities including anticancer, antibacterial and antioxidant properties. Momilactone A inhibits inflammatory responses by reducing NO production and iNOS expression. Momilactone A acts as a corrosion inhibitor for mild steel; it forms an isolating film on the metal surface via adsorption between oxygen atoms of the molecule and iron ions, thereby blocking corrosive media. Momilactone A inhibits the growth of fungal and bacterial organisms, and also functions as an allelochemical to inhibit the growth of adjacent competing plants. Momilactone A can be used in studies related to leukemia, fungal infections and bacterial infections.
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1,5-Hexadien-3-ol
0 ImagesCat. No.: HY-W169645CAS No.: 924-41-4Synonyms: NSC 1027611,5-Hexadien-3-ol is a green leaf volatile (GLV) alcohol that can be found in tomato plants. 1,5-Hexadien-3-ol contributes to protection against Botrytis cinerea. 1,5-Hexadien-3-ol can be used for the research of grey mould disease.
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Varacin
0 ImagesCat. No.: HY-N21817CAS No.: 134029-48-4Varacin is a benzopentathiepin polysulfide derived from marine ascidians. It exerts cytotoxic, antibacterial, and antifungal activities by cleaving DNA through a redox pathway. Varacin can be used in research on cancer, fungal infections, and bacterial infections.
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Antifungal agent 16
0 ImagesCat. No.: HY-132925CAS No.: 2762034-41-1Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively.
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Antimicrobial agent-4
0 ImagesCat. No.: HY-147944CAS No.: 2429922-67-6Antimicrobial agent-4 (compound 6a) is a potent antimicrobial agent. Antimicrobial agent-4 exhibits considerable activity against the microbial pathogens. Antimicrobial agent-4 delivers reliable toxicity to kill the bacteria and fungi. Antimicrobial agent-4 shows high binding energy value of −10.0 kcal/mole against the target enzyme.
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Iso-isariin B
0 ImagesCat. No.: HY-N12591CAS No.: 2326436-93-3Iso-isariin B is an analogue of cyclocarboxyphenate, which can be used in antifungal studies.
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Medicagenic acid 3-O-glucoside
0 ImagesCat. No.: HY-N17503CAS No.: 49792-23-6Medicagenic acid 3-O-glucoside is a monosaccharide-chain triterpenoid saponin antifungal agent that can be isolated from the roots of Medicago sativa. Against Pyricularia oryzae, Medicagenic acid 3-O-glucoside has a MIC of 0.03 mg/mL and a MFC of 0.125 mg/mL. Medicagenic acid 3-O-glucoside alters the permeability of fungal cell membranes, causing cell rupture and inhibiting fungal growth. Medicagenic acid 3-O-glucoside can be used in studies related to rice blast.
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Deferasirox methyl ester
0 ImagesDeferasirox methyl ester (compound 6a), a derivative of Deferasirox (HY-17359), is an antimicrobial agent. Deferasirox methyl ester exhibits activities against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candida albicans and Aspergillus niger with MICs of 0.5, 4.0, 1.0, 4.0, and 2.0 μg/mL, respectively. Deferasirox methyl ester can be used for antimicrobial research.
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Antifungal agent 64
0 ImagesCat. No.: HY-155669Antifungal agent 64 (Compound 5c) is a fungicidal agent with excellent fungicidal activities against Fusarium oxysporum f.sp. cucumerinum. Antifungal agent 64 can be used for antiviral and fungicidal research.
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Antifungal agent 78
0 ImagesCat. No.: HY-149603Antifungal agent 78 (compound 25am) is an antifungal agent with an EC50 value of 13.46 μM against F. graminearum.
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Salazinic acid
0 ImagesSalazinic acid has antibacterial activity against bacteria and fungi. Salazinic acid does not show antibacterial activity against Listeria monocytogenes, Pseudomonas aeruginosa, Yersinia enterocolitica, and Enterococcus faecalis, but it does have antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium.
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Retrocyclin-101
0 ImagesCat. No.: HY-P5642CAS No.: 536757-16-1Synonyms: RC-101Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression.
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Cyclo(Pro-dArg) acetate
0 ImagesCat. No.: HY-P10304DPurity: 98.12%Cyclo(Pro-dArg) acetate is a chitinase inhibitor. Cyclo(Pro-dArg) acetate inhibits the cell separation of Saccharomyces cerevisiae but does not affect its growth. Cyclo(Pro-dArg) acetate inhibits the transition of Candida albicans from yeast to filamentous morphology.
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Antifungal agent 12
0 ImagesCat. No.: HY-141812CAS No.: 2966848-11-1Antifungal agent 12 is a novel fluconazole-based compound with promising antifungal activities.
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CYP51-IN-26
0 ImagesCat. No.: HY-174973CYP51-IN-26 is a CYP51 inhibitor with an IC50 value of approximately 0.40 μM. CYP51-IN-26 eradicates C. auris biofilms. CYP51-IN-26 demonstrates significantly improved intracellular uptake in an accumulation assay. CYP51-IN-26 protects against C. auris infection in both G. mellonella and D. melanogaster models. CYP51-IN-26 can be used for research on fungal infections.
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3,5-Dimethyl-4-phenylisoxazole
0 ImagesCat. No.: HY-W840250CAS No.: 4345-46-4Synonyms: 3,5-Dimethyl-4-phenyl-1,2-oxazole3,5-Dimethyl-4-phenylisoxazole (3,5-Dimethyl-4-phenyl-1,2-oxazole) is a heterocyclic compound that serves as a molecular structural unit, exhibiting anti-inflammatory, anti-tumor, anti-bacterial, and anti-fungal properties, along with the capacity to modulate the immune system.
