Hsp90-IN-47
Hsp90-IN-47 (Compound C15) is a Hsp90 inhibitor and antifungal agent, with an IC50 of 0.014 μM against Hsp90α. When combined with Fluconazole (HY-B0101), Hsp90-IN-47 exerts significant synergistic antifungal effects against fluconazole-resistant Candida albicans 0304103. Hsp90-IN-47 exhibits antitumor activity against acute myeloid leukemia and non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 958888-13-6
- Formula: C17H18N4O3
- Molecular Weight:326.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HSP90α 0.014 μM (IC50) |
HDAC/HSP90-IN-5 (3 h) exerts potent inhibitory effects on Hsp90α, with an IC50 value of 0.014 μM[1].
The combination of HDAC/HSP90-IN-5 (48 h) and Fluconazole exerts a significant synergistic antifungal effect against Fluconazole-resistant Candida albicans 0304103, with a FICI of 0.063[1].
HDAC/HSP90-IN-5 (at a series of diluted concentrations; 48 h) exerts antiproliferative effects on HEL cells, HL60 cells and A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEL cell, HL60 cell, A549 cell
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Concentration:series diluted concentrations
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Incubation Time:48 h
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Result:Inhibited proliferation of HEL cells with an IC50 of 0.047±0.003 μM.
Inhibited proliferation of HL60 cells with an IC50 of 0.055±0.003 μM.
Inhibited proliferation of A549 cells with an IC50 of 0.65±0.14 μM.
Exerted strong proliferation inhibitory activity against leukemia cells HEL and HL60, and moderate proliferation inhibitory activity against lung cancer cell A549.
Chemical Information
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CAS No. 958888-13-6
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Molecular Weight 326.35
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Formula C17H18N4O3
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SMILES
O=C1NN=C(N1C2=CC=C(C=C2)N)C3=C(O)C=C(O)C(C(C)C)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hsp90-IN-47 Related Classifications
HY-186076 Related Classifications
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