2. Anti-infection
  3. Antibiotic Fungal Bacterial
  4. Terbinafine lactate

Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

CAS No. : 335276-86-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Terbinafine lactate:

Other Forms of Terbinafine lactate:

Terbinafine lactate Related Antibodies

Top Publications Citing Use of Products

    Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746.  [Abstract]

    Cell viabilities of CRC cell lines treated with Terbinafine at 10, 25, 50 μmol/L were accessed by CCK8 assay. DMSO was used as control.

    Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746.  [Abstract]

    Colony formation of CRC cell lines treated with Terbinafine at 50 μmol/L. DMSO was used as control.

    Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746.  [Abstract]

    Cell cycle analysis (G0/G1, S, G2/M phase) of HT29 cells treated with terbinafine at 10, 25, 50 μmol/L. DMSO was used as control.

    Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746.  [Abstract]

    Intracellular cholesterol levels of HT29 or RKO cells treated with Terbinafine at 10, 25, 50 μmol/L were accessed by cholesterol measurement. DMSO was used as control.

    Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746.  [Abstract]

    IHC analysis of Ki67 in HT29 and RKO cells‐derived xenograft tumors and treated with terbinafine (oral, 50 mg/kg).

    Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746.  [Abstract]

    Tumor growth curve of RKO cells treated with terbinafine (oral, 50 mg/kg) in nude mice.

    View All Antibiotic Isoform Specific Products:

    View All Isoforms
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

    In Vitro

    Terbinafine has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, and dimorphic and filamentous fungi. Terbinafine specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation. The treated fungal cells rapidly accumulate tlic intermediate squalene and become deficient in the end-product of the pathway, ergosterol[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Terbinafine lactate Related Antibodies
    In Vivo

    Terbinafine is not only active after topical application but is very effective in experimental dermatophytoses following oral administration. In fungi infected guinea-pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    381.51

    Formula

    C24H31NO3
    CAS No.
    SMILES

    CC(O)C(O)=O.CN(C/C=C/C#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Terbinafine lactate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Terbinafine335276-86-3TDT 067TDT067TDT-067AntibioticFungalBacterialinfectionsbacteriaCandidasqualene epoxidaseantibacterial activityInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Terbinafine lactate
    Cat. No.:
    HY-17395B
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.