Terbinafine-d3 hydrochloride
Based on 1 Customer Validation
Terbinafine-d3 hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1310012-15-7
- Formula: C21H23D3ClN
- Molecular Weight:330.91
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1310012-15-7
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Unlabeled Cas 78628-80-5
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Appearance Solid
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Molecular Weight 330.91
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Formula C21H23D3ClN
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Color White to off-white
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SMILES
CC(C)(C)C#C/C=C/CN(C([2H])([2H])[2H])CC1=CC=CC2=C1C=CC=C2.Cl
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Synonyms
TDT 067-d3 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
Ethanol : 30 mg/mL (90.66 mM; Need ultrasonic and warming)
DMSO : 10 mg/mL (30.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-8. [Content Brief]
[3]. Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-8. [Content Brief]
[4]. Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69(8):679-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / Ethanol | 1 mM | 3.0220 mL | 15.1098 mL | 30.2197 mL | 75.5492 mL |
| 5 mM | 0.6044 mL | 3.0220 mL | 6.0439 mL | 15.1098 mL | |
| 10 mM | 0.3022 mL | 1.5110 mL | 3.0220 mL | 7.5549 mL | |
| 15 mM | 0.2015 mL | 1.0073 mL | 2.0146 mL | 5.0366 mL | |
| 20 mM | 0.1511 mL | 0.7555 mL | 1.5110 mL | 3.7775 mL | |
| 25 mM | 0.1209 mL | 0.6044 mL | 1.2088 mL | 3.0220 mL | |
| 30 mM | 0.1007 mL | 0.5037 mL | 1.0073 mL | 2.5183 mL | |
| Ethanol | 40 mM | 0.0755 mL | 0.3777 mL | 0.7555 mL | 1.8887 mL |
| 50 mM | 0.0604 mL | 0.3022 mL | 0.6044 mL | 1.5110 mL | |
| 60 mM | 0.0504 mL | 0.2518 mL | 0.5037 mL | 1.2592 mL | |
| 80 mM | 0.0378 mL | 0.1889 mL | 0.3777 mL | 0.9444 mL |
Terbinafine-d3 hydrochloride Related Classifications
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