2. Others Anti-infection
  3. Isotope-Labeled Compounds Fungal Bacterial Antibiotic
  4. Terbinafine-d3 hydrochloride

Terbinafine-d3 hydrochloride  (Synonyms: TDT 067-d3 hydrochloride)

Cat. No.: HY-17395S Purity: ≥99.0%
COA Handling Instructions

Molarity Calculator

Terbinafine-d3 (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

For research use only. We do not sell to patients.

Terbinafine-d<sub>3</sub> hydrochloride Chemical Structure

Terbinafine-d3 hydrochloride Chemical Structure

CAS No. : 1310012-15-7

Size Price Stock Quantity
1 mg USD 470 In-stock
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Terbinafine-d3 hydrochloride:

Terbinafine-d3 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Antibiotic Isoform Specific Products:

View All Isoforms
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Terbinafine-d3 (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Terbinafine-d3 hydrochloride Related Antibodies
Molecular Weight

330.91

Formula

C21H23D3ClN
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C)C#C/C=C/CN(C([2H])([2H])[2H])CC1=CC=CC2=C1C=CC=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : 30 mg/mL (90.66 mM; Need ultrasonic and warming)

DMSO : 10 mg/mL (30.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0220 mL 15.1098 mL 30.2197 mL
5 mM 0.6044 mL 3.0220 mL 6.0439 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 3.0220 mL 15.1098 mL 30.2197 mL 75.5492 mL
5 mM 0.6044 mL 3.0220 mL 6.0439 mL 15.1098 mL
10 mM 0.3022 mL 1.5110 mL 3.0220 mL 7.5549 mL
15 mM 0.2015 mL 1.0073 mL 2.0146 mL 5.0366 mL
20 mM 0.1511 mL 0.7555 mL 1.5110 mL 3.7775 mL
25 mM 0.1209 mL 0.6044 mL 1.2088 mL 3.0220 mL
30 mM 0.1007 mL 0.5037 mL 1.0073 mL 2.5183 mL
Ethanol 40 mM 0.0755 mL 0.3777 mL 0.7555 mL 1.8887 mL
50 mM 0.0604 mL 0.3022 mL 0.6044 mL 1.5110 mL
60 mM 0.0504 mL 0.2518 mL 0.5037 mL 1.2592 mL
80 mM 0.0378 mL 0.1889 mL 0.3777 mL 0.9444 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Terbinafine-d3 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terbinafine-d31310012-15-7TDT 067-d3Isotope-Labeled CompoundsFungalBacterialAntibioticInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Terbinafine-d3 hydrochloride
Cat. No.:
HY-17395S
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.