2. NF-κB Immunology/Inflammation Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis Metabolic Enzyme/Protease
  3. Reactive Oxygen Species Calcium Channel Apoptosis Endogenous Metabolite
  4. L-Ascorbic acid-13C

L-Ascorbic acid-13C  (Synonyms: L-Ascorbate-13C; Vitamin C-13C)

Cat. No.: HY-B0166S1 Purity: 99.90%
COA Handling Instructions

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L-Ascorbic acid-13C is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

For research use only. We do not sell to patients.

L-Ascorbic acid-<sup>13</sup>C Chemical Structure

L-Ascorbic acid-13C Chemical Structure

CAS No. : 178101-88-7

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Ascorbic acid-13C:

L-Ascorbic acid-13C Related Antibodies

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Description

L-Ascorbic acid-13C is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ascorbic acid-13C Related Antibodies
Molecular Weight

177.12

Formula

C513CH8O6
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

OC([C@@]([H])([C@@H](O)CO)O[13C]1=O)=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (564.59 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6459 mL 28.2294 mL 56.4589 mL
5 mM 1.1292 mL 5.6459 mL 11.2918 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.6459 mL 28.2294 mL 56.4589 mL 141.1472 mL
5 mM 1.1292 mL 5.6459 mL 11.2918 mL 28.2294 mL
10 mM 0.5646 mL 2.8229 mL 5.6459 mL 14.1147 mL
15 mM 0.3764 mL 1.8820 mL 3.7639 mL 9.4098 mL
20 mM 0.2823 mL 1.4115 mL 2.8229 mL 7.0574 mL
25 mM 0.2258 mL 1.1292 mL 2.2584 mL 5.6459 mL
30 mM 0.1882 mL 0.9410 mL 1.8820 mL 4.7049 mL
40 mM 0.1411 mL 0.7057 mL 1.4115 mL 3.5287 mL
50 mM 0.1129 mL 0.5646 mL 1.1292 mL 2.8229 mL
60 mM 0.0941 mL 0.4705 mL 0.9410 mL 2.3525 mL
80 mM 0.0706 mL 0.3529 mL 0.7057 mL 1.7643 mL
100 mM 0.0565 mL 0.2823 mL 0.5646 mL 1.4115 mL
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L-Ascorbic acid-13C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ascorbic acid-13C178101-88-7L-Ascorbate-13CVitamin C-13CReactive Oxygen SpeciesCalcium ChannelApoptosisEndogenous MetaboliteCa2+ channelsCa channelsInhibitorinhibitorinhibit

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