2. Cell Cycle/DNA Damage Anti-infection
  3. Antifolate Bacterial Antibiotic
  4. Trimethoprim-d9

Trimethoprim-d9 is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3].

For research use only. We do not sell to patients.

Trimethoprim-d<sub>9</sub> Chemical Structure

Trimethoprim-d9 Chemical Structure

CAS No. : 1189460-62-5

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1 mg USD 170 In-stock
5 mg USD 370 In-stock
10 mg USD 590 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Trimethoprim-d9:

Trimethoprim-d9 Related Antibodies

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Description

Trimethoprim-d9 is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trimethoprim-d9 Related Antibodies
Molecular Weight

299.37

Formula

C14H9D9N4O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC=C(CC2=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C2)C(N)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (334.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3403 mL 16.7017 mL 33.4035 mL
5 mM 0.6681 mL 3.3403 mL 6.6807 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3403 mL 16.7017 mL 33.4035 mL 83.5087 mL
5 mM 0.6681 mL 3.3403 mL 6.6807 mL 16.7017 mL
10 mM 0.3340 mL 1.6702 mL 3.3403 mL 8.3509 mL
15 mM 0.2227 mL 1.1134 mL 2.2269 mL 5.5672 mL
20 mM 0.1670 mL 0.8351 mL 1.6702 mL 4.1754 mL
25 mM 0.1336 mL 0.6681 mL 1.3361 mL 3.3403 mL
30 mM 0.1113 mL 0.5567 mL 1.1134 mL 2.7836 mL
40 mM 0.0835 mL 0.4175 mL 0.8351 mL 2.0877 mL
50 mM 0.0668 mL 0.3340 mL 0.6681 mL 1.6702 mL
60 mM 0.0557 mL 0.2784 mL 0.5567 mL 1.3918 mL
80 mM 0.0418 mL 0.2088 mL 0.4175 mL 1.0439 mL
100 mM 0.0334 mL 0.1670 mL 0.3340 mL 0.8351 mL
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Trimethoprim-d9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trimethoprim-d91189460-62-5AntifolateBacterialAntibioticInhibitorinhibitorinhibit

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