Bexarotene-d4
Based on 1 Customer Validation
Bexarotene-d4 is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma.
For research use only. We do not sell to patients.
- Purity: 98.51%
- CAS No.: 2182068-00-2
- Formula: C24H24D4O2
- Molecular Weight:352.50
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2182068-00-2
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Unlabeled Cas 153559-49-0
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Appearance Solid
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Molecular Weight 352.50
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Formula C24H24D4O2
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Color White to off-white
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SMILES
CC1(C2=C(C(C)(CC1)C)C=C(C(C(C3=C([2H])C([2H])=C(C([2H])=C3[2H])C(O)=O)=C)=C2)C)C
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Synonyms
LGD1069 d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMF : ≥ 20 mg/mL (56.74 mM)
DMSO : ≥ 10 mg/mL (28.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : ≥ 0.5 mg/mL (1.42 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Vakeva L, Ranki A, Hahtola S. Ten-year experience of bexarotene therapy for cutaneous T-cell lymphoma in Finland. Acta Derm Venereol. 2012 May;92(3):258-63. doi: 10.2340/00015555-1359. [Content Brief]
[2]. Gui Y, et al. Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1. J Pain. 2019 Jan 17. pii: S1526-5900(18)30607-2. [Content Brief]
[3]. Zhang X, Schlaak M, Fabri M, Mauch C, Kurschat P. Successful Treatment of a Panniculitis-Like Primary Cutaneous T-Cell Lymphoma of the α/β Type with Bexarotene. Case Rep Dermatol. 2012 Jan;4(1):56-60. [Content Brief]
[4]. Orendas P, Kubatka P, Kajo K, Stollarova N, Kassayova M, Bojkova B, Pec M, Nosal V, Kiskova T, Zihlavnikova K, Karsnakova R. Melatonin enhanced bexarotene efficacy in experimental mammary carcinogenesis. Neoplasma. 2012;59(4):469-74. [Content Brief]
[5]. Cras A, Politis B, Balitrand N, Darsin-Bettinger D, Boelle PY, Cassinat B, Toubert ME, Chomienne C. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| Ethanol / DMSO / DMF | 1 mM | 2.8369 mL | 14.1844 mL | 28.3688 mL | 70.9220 mL |
| DMSO / DMF | 5 mM | 0.5674 mL | 2.8369 mL | 5.6738 mL | 14.1844 mL |
| 10 mM | 0.2837 mL | 1.4184 mL | 2.8369 mL | 7.0922 mL | |
| 15 mM | 0.1891 mL | 0.9456 mL | 1.8913 mL | 4.7281 mL | |
| 20 mM | 0.1418 mL | 0.7092 mL | 1.4184 mL | 3.5461 mL | |
| 25 mM | 0.1135 mL | 0.5674 mL | 1.1348 mL | 2.8369 mL | |
| DMF | 30 mM | 0.0946 mL | 0.4728 mL | 0.9456 mL | 2.3641 mL |
| 40 mM | 0.0709 mL | 0.3546 mL | 0.7092 mL | 1.7730 mL | |
| 50 mM | 0.0567 mL | 0.2837 mL | 0.5674 mL | 1.4184 mL |
Bexarotene-d4 Related Classifications
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