1. Anti-infection
  2. Fungal
  3. Terbinafine

Terbinafine (Synonyms: TDT 067)

Cat. No.: HY-17395A Purity: 98.83%
Handling Instructions

Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM.

For research use only. We do not sell to patients.

Terbinafine Chemical Structure

Terbinafine Chemical Structure

CAS No. : 91161-71-6

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10 mM * 1 mL in DMSO USD 66 In-stock
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100 mg USD 60 In-stock
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200 mg USD 106 In-stock
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Description

Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM.

IC50 & Target

Ki: 30 nM (squalene epoxidase)[1]

In Vitro

Terbinafine has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, and dimorphic and filamentous fungi. Terbinafine specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation. The treated fungal cells rapidly accumulate tlic intermediate squalene and become deficient in the end-product of the pathway, ergosterol[1].

In Vivo

Terbinafine is not only active after topical application but is very effective in experimental dermatophytoses following oral administration. In fungi infected guinea-pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine[2].

Clinical Trial
Molecular Weight

291.43

Formula

C₂₁H₂₅N

CAS No.

91161-71-6

SMILES

CN(C/C=C/C#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (343.14 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4314 mL 17.1568 mL 34.3136 mL
5 mM 0.6863 mL 3.4314 mL 6.8627 mL
10 mM 0.3431 mL 1.7157 mL 3.4314 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (8.58 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (8.58 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
Animal Administration
[2]

Guinea-pigs: The backs (lumbar regions) of guinea-pigs, which have been mechanically depilated, are infected with 0.1 mL Sabouraud's dextrose 2% broth containing 106 c.f.u. of Truhophyton mentagrophytes. The treatments commence 48 h post-inoculation. The test compounds (Terbinafine) are suspended in 2% tylose and Tween 80 and administered via a stomach tube once daily on 9 consecutive days, or dissolved in a mixture of polyethylene glycol 400 and etbanol and spread on the infected part ot the body in a volume of 0.4 mL with a Hrigalski spatula once daily for 1-7 consecutive days[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 98.83%

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Keywords:

TerbinafineTDT 067TDT067TDT-067FungalInhibitorinhibitorinhibit

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Terbinafine
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HY-17395A
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