1. Protein Tyrosine Kinase/RTK Anti-infection Metabolic Enzyme/Protease
  2. VEGFR Bacterial Dihydrofolate reductase (DHFR) Fungal
  3. VEGFR-2/DHFR-IN-1

VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

VEGFR-2/DHFR-IN-1 Chemical Structure

VEGFR-2/DHFR-IN-1 Chemical Structure

CAS No. : 2831498-15-6

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Description

VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer[1].

IC50 & Target

VEGFR-2

0.384 μM (IC50)

DHFR

7.881 μM (IC50)

In Vitro

VEGFR-2/DHFR-IN-1 (2-1024 μg/mL; 18-72 h) shows antibacterial and antifungal activities with MIC values of 16, 64, 16, 16, 8, 16, 64 and 256 μg/mL for Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Salmonella enterica, MSSA, MRSA, Candida albicans and Aspergillus niger, respectively[1].
VEGFR-2/DHFR-IN-1 (0.5-100 μM; 48 h) exhibits anticancer activities[1].
VEGFR-2/DHFR-IN-1 (0-100 μM; 30 min) shows DHFR and VEGFR-2 inhibitory activities with IC50s of 7.881 and 0.384 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: C26, HepG2, MCF7 and H69PR cell lines
Concentration: 0.5, 1, 5, 10, 25, 50, 80 and 100 μM
Incubation Time: 48 hours
Result: Showed anticancer activities to C26, HepG2, MCF7 and H69PR cells with IC50s of 2.97, 7.12, 3.58 and 12.79 μM, respectively.
Molecular Weight

371.81

Formula

C20H18ClNO4

CAS No.
SMILES

O=C(NCC1=CC=C(Cl)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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VEGFR-2/DHFR-IN-1
Cat. No.:
HY-151458
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