VEGFR-2/DHFR-IN-1
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2831498-15-6
- Formula: C20H18ClNO4
- Molecular Weight:371.81
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All VEGFR Isoforms
More
Biological Activity
|
VEGFR-2 0.384 μM (IC50) |
DHFR 7.881 μM (IC50) |
VEGFR-2/DHFR-IN-1 (2-1024 μg/mL; 18-72 h) shows antibacterial and antifungal activities with MIC values of 16, 64, 16, 16, 8, 16, 64 and 256 μg/mL for Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Salmonella enterica, MSSA, MRSA, Candida albicans and Aspergillus niger, respectively[1]. VEGFR-2/DHFR-IN-1 (0.5-100 μM; 48 h) exhibits anticancer activities[1]. VEGFR-2/DHFR-IN-1 (0-100 μM; 30 min) shows DHFR and VEGFR-2 inhibitory activities with IC50s of 7.881 and 0.384 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:C26, HepG2, MCF7 and H69PR cell lines
-
Concentration:0.5, 1, 5, 10, 25, 50, 80 and 100 μM
-
Incubation Time:48 hours
-
Result:Showed anticancer activities to C26, HepG2, MCF7 and H69PR cells with IC50s of 2.97, 7.12, 3.58 and 12.79 μM, respectively.
Chemical Information
-
CAS No. 2831498-15-6
-
Molecular Weight 371.81
-
Formula C20H18ClNO4
-
SMILES
O=C(NCC1=CC=C(Cl)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR-2/DHFR-IN-1 Related Classifications
HY-151458 Related Classifications
Powered by Bioz