2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P3906
    Melittin free acid
    		Inhibitor
    Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways.
    Melittin free acid
  • HY-B0454S
    Miconazole-d5
    		Inhibitor
    Miconazole-d5 is the deuterium labeled Miconazole. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects.
    Miconazole-d<sub>5</sub>
  • HY-B0850S
    Difenoconazole-d6 hydrochloride
    		Inhibitor
    Difenoconazole-d6 (hydrochloride) is deuterium labeled Difenoconazole. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth.
    Difenoconazole-d<sub>6</sub> hydrochloride
  • HY-126644
    Halocyamine B
    		Inhibitor
    Halocyamine B exhibits antimicrobial activity against a variety of bacteria and yeasts. Halocyamine B exhibits cytotoxicity to cultured neural cells of rat fetal brain, mouse neuroblastoma N18 cells, and human hepatoma HepG2 cells.
    Halocyamine B
  • HY-B1975
    Dithianon
    		Inhibitor
    Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others.
    Dithianon
  • HY-116128
    Brassilexin
    Brassilexin is a sulphur-containing phytoalexin, that can be isolated from Brassica juncea L., (cruciferae).
    Brassilexin
  • HY-N20641
    Turonicin A
    		Inhibitor
    Turonicin A is an anti-fungal and anti-bacterial agent found in Australian Streptomyces sp. MST-123921. Turonicin A inhibits growth of Candida albicans and Saccharomyces cerevisiae fungi. Turonicin A inhibits growth of Bacillus subtilis and Staphylococcus aureus bacteria. Turonicin A can be used for the research of fungal infections, bacterial infections.
    Turonicin A
  • HY-N6739R
    Beauvericin (Standard)
    		Inhibitor
    Doxycycline (monohydrate) (Standard) is the analytical standard of Doxycycline (monohydrate). This product is intended for research and analytical applications. Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor.
    Beauvericin (Standard)
  • HY-P11342
    Verlamelin A
    		Inhibitor
    Verlamelin A is a macrocyclic depsipeptide with antifungal and antiviral activity. Verlamelin A shows antifungal activity toward Aspergillus versicolor and Curvularia australiensis and also has antiviral activity toward HSV-1 (IC50 = 16.7 μM). Verlamelin A is isolated from the entomopathogenic fungus Lecanicillium sp. Verlamelin A is useful for antifungal and antiviral research.
    Verlamelin A
  • HY-N11772R
    Mutanocyclin (Standard)
    		Inhibitor
    Taurodeoxycholate (sodium salt) (Standard) is the analytical standard of Taurodeoxycholate (sodium salt). This product is intended for research and analytical applications. Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) inhibits various inflammatory responses .
    Mutanocyclin (Standard)
  • HY-129642
    Hirsutide
    Hirsutide is a cyclic tetrapeptide that can be found in spider-derived entomopathogenic fungus.
    Hirsutide
  • HY-U00007
    Stilbamidine
    		Inhibitor
    Stilbamidine is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.
    Stilbamidine
  • HY-114335
    Triphala
    		Inhibitor
    Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits NF-κB activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.
    Triphala
  • HY-N2229R
    Rhapontigenin (Standard)
    		Inhibitor
    Rhapontigenin (Standard) is the analytical standard of Rhapontigenin. This product is intended for research and analytical applications. Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50 = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively.
    Rhapontigenin (Standard)
  • HY-152138
    Antituberculosis agent-8
    		Inhibitor
    Antituberculosis agent-8 (Compound 9i) is an antitubercular agent with an MIC of 3.53 μM (1.6 μg/mL) against M. tuberculosis H37Rv. Antituberculosis agent-8 also shows good antifungal activity against A. niger with an MIC of 62.50 μM.
    Antituberculosis agent-8
  • HY-N15755
    Sepiumol A
    		Inhibitor
    Sepiumol A is a polyphenolic compound that can be isolated from the bark of Periploca sepium Bunge. Sepiumol A has antibacterial and antifungal activities. Sepiumol A can be added to e-cigarette liquid to exert antibacterial effects and reduce the sweetness and greasiness during smoking.
    Sepiumol A
  • HY-116158
    Oosponol
    		Antagonist
    Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi.
    Oosponol
  • HY-B1324A
    Oxiconazole
    		Inhibitor
    Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.
    Oxiconazole
  • HY-B2048
    Pencycuron
    		Inhibitor
    Pencycuron is a benzoylurea fungicide. Pencycuron kills fungi by inhibiting the synthesis of fungal cell walls.Pencycuron can be used in research on the control of fungal diseases on crops, such as sheath blight, powdery mildew and late blight.
    Pencycuron
  • HY-178177
    SDH-IN-31
    		Inhibitor
    SDH-IN-31 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.11 μM. SDH-IN-31 exhibits anti-fungal activity. SDH-IN-31 can be used for the research of infection, such as infection, such as rice sheath blight.
    SDH-IN-31
Cat. No. Product Name / Synonyms Application Reactivity