Melittin free acid
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways.
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- CAS. Nr.: 123168-46-7
- Formel: C131H228N38O32
- Molecular Weight:2847.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
Melittin free acid stimulates the biosynthesis of prostaglandins by mouse transformed fibroblasts (MC5-5), human fibroblasts (D550), rabbit aorta endothelial cells (CLO), rat lung type II alveolar pneumocytes (L-2) and rabbit smooth muscle cells (R-I)[1]. Melittin free acid stimulates the release of arachidonic acid from the cellular phospholipids of MC5-5 cells[1]. Melittin free acid induces the accumulation of ROS in germinating conidia of A. flavus[2]. Melittin free acid inhibits B. cinerea MUCL 30158 and CECT 2100 strains with IC50 values of 3.1 and 24 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 123168-46-7
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Molecular Weight 2847.45
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Formel C131H228N38O32
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Sequence Shortening
GIGAVLKVLTTGLPALISWIKRKRQQ
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Hassid A, Levine L. Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo. Res Commun Chem Pathol Pharmacol. 1977. [Content Brief]
[2]. Memariani H, Memariani M. Anti-fungal properties and mechanisms of melittin. Appl Microbiol Biotechnol. 2020 Aug;104(15):6513-6526. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Melittin free acid Related Classifications
HY-P3906 Related Classifications
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