1. Anti-infection Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  2. Fungal Apoptosis Phospholipase Reactive Oxygen Species
  3. Melittin free acid

Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways.

For research use only. We do not sell to patients.

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Melittin free acid Chemical Structure

Melittin free acid Chemical Structure

CAS No. : 123168-46-7

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Description

Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2].

In Vitro

Melittin free acid stimulates the biosynthesis of prostaglandins by mouse transformed fibroblasts (MC5-5), human fibroblasts (D550), rabbit aorta endothelial cells (CLO), rat lung type II alveolar pneumocytes (L-2) and rabbit smooth muscle cells (R-I)[1].
Melittin free acid stimulates the release of arachidonic acid from the cellular phospholipids of MC5-5 cells[1].
Melittin free acid induces the accumulation of ROS in germinating conidia of A. flavus[2].
Melittin free acid inhibits B. cinerea MUCL 30158 and CECT 2100 strains with IC50 values of 3.1 and 24 μM, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Melittin (intraperitoneal inoculation) increases 13,14-dihydro-15-keto-PGE2 levels in peripheral blood of mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2847.45

Formula

C131H228N38O32

CAS No.
Sequence Shortening

GIGAVLKVLTTGLPALISWIKRKRQQ

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Melittin free acid
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HY-P3906
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