2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W754654
    Epothilone B-d3 (synthetic)
    Epothilone B-d3 (synthetic) is the deuterium labeled Epothilone B (HY-17029). Epothilone B is a microtubule stabilizer with a Ki of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation.
    Epothilone B-d<sub>3</sub> (synthetic)
  • HY-129291
    Reductiomycin
    		Inhibitor
    Reductiomycin is an antibiotic, which exhibits antimicrobial activity against gram positive bacteria and fungi. Reductiomycin exhibits antitumor activity.
    Reductiomycin
  • HY-172777
    SDH-IN-25
    		Inhibitor
    SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control.
    SDH-IN-25
  • HY-147999
    GlcN-6-P Synthase-IN-1
    		Inhibitor
    GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform.
    GlcN-6-P Synthase-IN-1
  • HY-N8507
    Tunicamycin B
    		Inhibitor
    Tunicamycin B is a Tunicamycin (HY-A0098) derivative with antimicrobial activity. Tunicamycin B shows antibacterial activity against Bacillus thuringiensis BT01 and B. thuringiensis W102 (MICs of 0.125 and 0.063 μg/mL, respectively) and antifungal activity against Candida albicans ATCC 96901 and C. albicans CMCC (F) 98001 (MICs of 8.0 and 4.0 μg/mL, respectively). Tunicamycin B can be used for antimicrobial research.
    Tunicamycin B
  • HY-137989S
    Voriconazole N-oxide-d3
    		Inhibitor
    Voriconazole N-oxide-d3 (Voriconazole oxynitride-d3) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB).
    Voriconazole N-oxide-d<sub>3</sub>
  • HY-W743904
    Quininone
    		Inhibitor
    Quininone is a Quinine (HY-D0143) derivative that exhibits in vitro antifungal activity. Quininone can be used for antifungal research.
    Quininone
  • HY-N4145
    Procyanidin A3
    		Inhibitor
    Procyanidin A3 (Cinnamtannin A3; Cinnamtannin II) is a sub class of Proanthocyanidins (HY-N0794). Proanthocyanidin are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancer agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy.
    Procyanidin A3
  • HY-121163
    PF-184563
    Janthitrem F is a metabolite isolated from tremorigen-producing Penicillium and a potential causative agent of ryegrass spurt disease.
    PF-184563
  • HY-P1940R
    Maculosin (Standard)
    		Inhibitor
    Complanatuside (Standard) is the analytical standard of Complanatuside. This product is intended for research and analytical applications. Complanatuside is a flavonoid found in the traditional Chinese medicine Semen Astragali Complanati.
    Maculosin (Standard)
  • HY-120333
    Antibiotic PF 1052
    		Inhibitor
    Antibiotic PF 1052 is an antibiotic extracted from a natural product library. Antibiotic PF 1052 has an inhibitory effect on murine neutrophil migration.
    Antibiotic PF 1052
  • HY-P10254
    Iso-phytochelatin 2 (Glu)
    Iso-phytochelatin 2 Glu is chelating peptide with general structure (γ-Glu-Cys)n-Gly, which is induced by heavy metals in high plants and fungi.
    Iso-phytochelatin 2 (Glu)
  • HY-N19684
    3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl
    3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl is a biphenyl compound found in Monnina obtusifolia. 3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl has antifungal activity.
    3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl
  • HY-N11241
    Cascaroside B
    		Inhibitor
    Cascaroside B is a flavonoid and antifungal agent found in the Pseudomonas aeruginosa Ld-08.
    Cascaroside B
  • HY-17583S
    Griseofulvin-d3
    		Inhibitor
    Griseofulvin-d3 is the deuterium labeled Griseofulvin. Griseofulvin (Gris-PEG) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal agent.
    Griseofulvin-d<sub>3</sub>
  • HY-162329
    Antibacterial agent 195
    		Inhibitor
    Antibacterial agent 195 (compound A20), a Matrine (HY-N0164) derivative, is a potent antibiotic. Antibacterial agent 195 shows antibacterial activity against Gram-positive bacterium (MICS.aureus=0.021 mg/mL; MICP.acnes=0.030 mg/mL), Gram-negative bacterium (MICE.coli=0.092 mg/mL; MICC.albicans=0.379 mg/mL) and Fungus (MIC=2.806 mg/mL).
    Antibacterial agent 195
  • HY-N10423
    Cubebin
    		Inhibitor
    Cubebin ((-)-Cubebin), a dibenzyl butyrolactone lignan, is an orally active AChE inhibitor. Cubebin binds to active sites of NF-κB, TNF-α, and TGF-β1 via hydrogen and hydrophobic interactions, obstructing critical residues to inhibit pro-inflammatory or renal fibrosis-related activity. Cubebin enhances p38 MAPK phosphorylation to increase tyrosinase gene expression, stimulating melanogenesis via elevated tyrosinase activity, expression, and mRNA levels. Cubebin reduces oxidative stress via enhanced endogenous antioxidant enzyme activity and inhibited lipid peroxidation, regulates lipid metabolism, improves glycemic control, and exerts renoprotective effects via reduced renal dysfunction markers and improved renal architecture. Cubebin shows antimicrobial activity. Cubebin exerts larvicidal activity against Angiostrongylus cantonensis larvae, with no cytotoxicity toward monkey or human cell lines or Caenorhabditis elegans. Cubebin can be used for the research of diabetic nephropathy, melanoma, colon adenocarcinoma, neuroangiostrongyliasis, Alzheimer’s disease (AD) and depression.
    Cubebin
  • HY-139851
    Fungicide5
    		Inhibitor
    Fungicide5 is a fungicide candidate targeting succinate dehydrogenase (Ki = 0.095 μM).
    Fungicide5
  • HY-D0162R
    Malachite green hemioxalate (Standard)
    		Inhibitor
    Malachite green hemioxalate (Standard) is the analytical standard of Malachite green hemioxalate (HY-D0162). This product is intended for research and analytical applications. Malachite green hemioxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antimicrobial activity, which is attributed to inhibition of intracellular enzymes, intercalation into DNA, and/or interaction with cellular membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo.
    Malachite green hemioxalate (Standard)
  • HY-142912
    Stemphyperylenol
    Stemphyperylenol displays a potent antifungal activity against the plant pathogen Alternaria solani with MIC of 1.57 μM.
    Stemphyperylenol
Cat. No. Product Name / Synonyms Application Reactivity