PF-184563
Janthitrem F is a metabolite isolated from tremorigen-producing Penicillium and a potential causative agent of ryegrass spurt disease.
For research use only. We do not sell to patients.
- CAS No.: 748806-39-5
- Formula: C21H23ClN6
- Molecular Weight:394.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Penicillium sp.[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
6.7 nM
Compound: 13d, PF-184563
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Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
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[PMID: 21885275] |
| HEK293 | IC50 |
17900 nM
Compound: 13d, PF-184563
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Displacement of [3H]dofetilide from human ERG transfected in HEK293 cells by fluorescence polarization binding assay
Displacement of [3H]dofetilide from human ERG transfected in HEK293 cells by fluorescence polarization binding assay
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[PMID: 21885275] |
Chemical Information
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CAS No. 748806-39-5
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Molecular Weight 394.90
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Formula C21H23ClN6
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SMILES
CN1CC2=CC(Cl)=CC=C2N3C(C4CCN(CC4)C5=NC=CC=C5)=NN=C3C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-184563 Related Classifications
HY-121163 Related Classifications
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