2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N17760
    (25RS)-Schidigera-saponin E1
    		Inhibitor
    (25RS)-Schidigera-saponin E1 is a steroidal saponin with anti-yeast activity, which can be isolated from the stems of Yucca schidigera (Mojave yucca). (25RS)-Schidigera-saponin E1 exerts weak anti-yeast activity by affecting the integrity of microbial cell membranes, with a MIC≥100 μg/mL against some food spoilage yeasts. (25RS)-Schidigera-saponin E1 can be used in the field of food preservation to extend the shelf life of foods containing cooked rice, beans, fermented condiments, etc.
    (25RS)-Schidigera-saponin E1
  • HY-N1289
    Sequosempervirin B
    		Inhibitor
    Sequosempervirin B, a norlignan isolated from the branches and leaves of Sequoia sempervirens, has antifungal properties. Sequosempervirin B has an inhibitory effect on cyclic AMP phosphodiesterase.
    Sequosempervirin B
  • HY-151423
    Antifungal agent 39
    		Inhibitor
    Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent.
    Antifungal agent 39
  • HY-N0415R
    Trigonelline chloride (Standard)
    		Inhibitor
    Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.
    Trigonelline chloride (Standard)
  • HY-23155S
    2-Phenylethyl isothiocyanate-d5
    2-Phenylethyl isothiocyanate-d5 isothiocyanate-d5 is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].
    2-Phenylethyl isothiocyanate-d<sub>5</sub>
  • HY-N6726S1
    Fumonisin B3-13C34-1
    Fumonisin B3-13C34-1 is the isotopic internal standard of Fumonisin B3 (HY-N6726). Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma.
    Fumonisin B3-<sup>13</sup>C<sub>34</sub>-1
  • HY-123155
    Pyrimorph
    		Inhibitor
    Pyrimorph is a fungicide with excellent antifungal activity against oomycetes.
    Pyrimorph
  • HY-133169
    Topazolin
    		Inhibitor
    Topazolin is a flavone. Topazolin has weak fungi-toxic activity against Cladosporium herbarum AHU 9262.
    Topazolin
  • HY-N10611
    Elsinochrome A
    		Inhibitor
    Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm).
    Elsinochrome A
  • HY-113219S
    Hydroxyphenyllactic acid-d4
    Hydroxyphenyllactic acid-d4 is the deuterium labeled Hydroxyphenyllactic acid (HY-113219). Hydroxyphenyllactic acid is an antifungal metabolite.
    Hydroxyphenyllactic acid-d<sub>4</sub>
  • HY-N7519
    5-(12Z-Heptadecenyl)-resorcinol
    		Inhibitor
    5-(12Z-Heptadecenyl)-resorcinol (Compound 1a) serves as the main component of Antifungal mixtures. 5-(12Z-Heptadecenyl)-resorcinol can be isolated from mango peels. Antifungal mixtures composed of 5-(12Z-Heptadecenyl)-resorcinol exhibit activity against Alternaria alternata. 5-(12Z-Heptadecenyl)-resorcinol can be used in studies related to mango fruit black spot disease.
    5-(12Z-Heptadecenyl)-resorcinol
  • HY-N8258
    Aszonapyrone A
    Aszonapyrone A is a metabolite produced by Aspergillus zonatus.
    Aszonapyrone A
  • HY-W116336B
    Zinc oxide, 99.99% metals basis
    		Inhibitor 99.99%
    Zinc oxide, 99.99% metals basis is a versatile wide-bandgap semiconductor with superior comprehensive properties. Zinc oxide, 99.99% metals basis serves as raw material for Schottky diodes, functional nanostructures, sensors, energy harvesters and photocatalysts for hydrogen production. Zinc oxide, 99.99% metals basis acts as a non-toxic antibacterial agent and selective cytotoxin against multiple bacteria, fungi and spores. Zinc oxide, 99.99% metals basis induces cancer cell death. Zinc oxide, 99.99% metals basis is applicable to drug delivery, biosensing, bioimaging and researches on cancer, microbial infections and skin diseases.
    Zinc oxide, 99.99% metals basis
  • HY-B0996R
    Hexetidine (Standard)
    		Inhibitor
    Hexetidine (Standard) is the analytical standard of Hexetidine. This product is intended for research and analytical applications. Hexetidine is an orally active antiseptic with broad antibacterial and antifungal activity. Hexetidine give important potential for treatment of oral infections.
    Hexetidine (Standard)
  • HY-124894
    (+)-Benalaxyl
    		Inhibitor
    (+)-Benalaxyl is a broad-spectrum benzamide fungicide. (+)-Benalaxyl inhibits the growth of the freshwater algae S. obliquus, with an EC50 value of 8.441 mg/L. (+)-Benalaxyl can induce the production of chlorophyll a and b, as well as increase the activity of superoxide dismutase (SOD) and the generation of malondialdehyde (MDA). (+)-Benalaxyl has inhibitory effects on catalase (CAT). (+)-Benalaxyl is effective against diseases caused by oomycetes.
    (+)-Benalaxyl
  • HY-N2640
    4-O-Methylsappanol
    		Inhibitor
    4-O-Methylsappanol is a natural isoflavonoid with antifungal activities. 4-O-Methylsappanol shows activity against Beauveria bassiana. 4-O-Methylsappanol (EC50 of 4.6 μM) strongly suppresses Melanin (Melanin) synthesis in HMV-II cells.
    4-O-Methylsappanol
  • HY-N11079
    Toonaciliatin M
    		Inhibitor
    Toonaciliatin M (compound 6) is a pmaradiene-type diterpenoid that can be isolated from Toona ciliate. Toonaciliatin M show antifungal activity against Trichophyton rubrum with an MIC value of 12.5 µg/mL.
    Toonaciliatin M
  • HY-171542
    CDA-IN-2
    		Inhibitor
    CDA-IN-2 (Compound VS#2-3) is a chitin deacetylase (Chitin Deacetylase, CDA) inhibitor with antifungal activity. At a concentration of 100 μM, it can inhibit the CDA PxCDA1 and PxCDA2 of P. xanthii by 83.7% and 74.5% respectively. CDA-IN-2 can be applied to the research in the field of controlling agricultural fungal diseases, such as dealing with resistant powdery mildew and Botrytis cinerea .
    CDA-IN-2
  • HY-B1460B
    Sulconazole
    		Inhibitor
    Sulconazole is a potent antifungal agent in the imidazole class. Sulconazole blocks the NF-κB/IL-8 signaling pathway and CSC (Cancer stem cells) formation. Sulconazole inhibits tumor growth, and can be used for breast cancer research.
    Sulconazole
  • HY-W765245
    Rapamycin-13C,d3-1
    Rapamycin-13C,d3-1 (Sirolimus-13C,d3-1) is the deuterium labeled and 13C-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.
    Rapamycin-<sup>13</sup>C,d<sub>3</sub>-1
Cat. No. Product Name / Synonyms Application Reactivity