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Cat. No.: HY-151423

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Antifungal agent 39

Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent.

For research use only. We do not sell to patients.

CAS No.: 2725074-94-0
Formula: C₂₃H₂₂ClN₃O₅
Molecular Weight:455.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antifungal agent 39 Chemical Structure

CAS No.: 2725074-94-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent^[1].

IC₅₀ & Target

Fungal^[1]

In Vitro

Antifungal agent 39 (Compound 9h) (0-512 μg/mL; 24 h) shows excellent antifungal activity against C. albicans and displays good antifungal activity against A. fumigatus and C. neoformans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

C. albicans (ATCC 76615), A. flavus (ATCC 16870), A. fumigatus (GIMCC 3.19) and C. neoformans (ATCC 208821)
Concentration:

0-512 μg/mL
Incubation Time:

24 h
Result:

Showed inhibition with MICs of 16 ± 0, 64 ± 0, 32 ± 0 and 32 ± 0 μg/mL against C. albicans (ATCC 76615), A. flavus (ATCC 16870), A. fumigatus (GIMCC 3.19) and C. neoformans (ATCC 208821), respectively.

Chemical Information

CAS No. 2725074-94-0
Molecular Weight 455.89
Formula C₂₃H₂₂ClN₃O₅
SMILES

O=C(NC1=CC=CC=C1Cl)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu Y, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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