2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-168446
    PKR-IN-1
    		Inhibitor
    PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor that has antifungal activity, with an EC50 of 0.21 μg/mL for R. solani.
    PKR-IN-1
  • HY-173428
    Antifungal agent 130
    		Inhibitor
    Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections.
    Antifungal agent 130
  • HY-N14826
    Nanaomycin E
    		Inhibitor
    Nanaomycin E is an antibiotic. Nanaomycin E has activity against Gram-positive bacteria and fungi.
    Nanaomycin E
  • HY-N13916
    Alternaric acid
    Alternaric acid is a host-specific toxin produced by the plant fungal. In the presence of Ca2+ and Mg2+, Alternaric acid stimulates phosphorylation of His-tagged cytosolic kinase RiCDPK2.
    Alternaric acid
  • HY-N19846
    Pithecolobine
    		Inhibitor
    Pithecolobine is a saponin-like alkaloid found in the bark, seeds, and leaves of Samanea saman. Pithecolobine can inhibit the growth of Gram-positive bacteria, Gram-negative bacteria, and pathogenic yeasts. Pithecolobine scavenges DPPH radicals. Pithecolobine can be used for the research of infections caused by pathogenic bacteria and yeasts.
    Pithecolobine
  • HY-N14808
    Neobulgarone B
    		Inhibitor
    Neobulgarone B is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone B can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone B
  • HY-B0364AR
    Dyclonine hydrochloride (Standard)
    		Inhibitor
    Dyclonine (hydrochloride) (Standard) is the analytical standard of Dyclonine (hydrochloride). This product is intended for research and analytical applications. Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain.
    Dyclonine hydrochloride (Standard)
  • HY-N7236
    Pervicoside B
    		Inhibitor
    Pervicoside B is a glycoside C isolated from Neothyone gibbosa sea cucumber. In vitro studies have shown that Pervicoside B has a potent antiparasitic effect against Leishmania mexicana, inhibiting 100% of promastigotes at 5-10 μg/mL. Pervicoside B also exhibits strong antifungal activity against Aspergillus niger, with MIC values ranging from 4.65 to 16.7 μg/mL. Pervicoside B has potential applications in the inhibition of parasitic infections and fungal diseases.
    Pervicoside B
  • HY-133087
    Oxathiapiprolin
    		Inhibitor
    Oxathiapiprolin is an anti-phytopathogenic oomycete agent. Oxathiapiprolin inhibits mycelial growth, sporangium production, zoospore release and zoospore motility in specific oomycetes. Oxathiapiprolin exhibits both protective and therapeutic activities against Phytophthora capsici infection in pepper plants. Oxathiapiprolin can be used in studies related to plant diseases.
    Oxathiapiprolin
  • HY-17521
    Flumorph
    		Inhibitor 99.57%
    Flumorph (SYP-L190) is a carboxylic acid amide fungicide. Flumorph inhibits the polar growth of Phytophthora melonis by disrupting the arrangement of filamentous actin. Flumorph can be used to study Phytophthora melonis infection.
    Flumorph
  • HY-10980R
    Tavaborole (Standard)
    		Inhibitor
    Tavaborole (Standard) is the analytical standard of Tavaborole. This product is intended for research and analytical applications. Tavaborole (AN-2690) is an antifungal agent with activity against Trichophyton species, in a topical solution formulation for the potential treatment of onychomycosis.
    Tavaborole (Standard)
  • HY-N3569
    Cerbinal
    		Inhibitor
    Cerbinal is a natural compound isolated from Gardenia jasminoides Ellis. Cerbinal has antifungal activity.
    Cerbinal
  • HY-W895978
    Isoconazole
    		Inhibitor
    Isoconazole is an antifungal agent against Candida albicans. Isoconazole is a broad-spectrum antimicrobial azole that can be studied in research on dermatomycoses.
    Isoconazole
  • HY-107211
    Echinocandin B nucleus
    		Control
    Echinocandin B nucleus (A-30912 A nucleus) is the reaction product catalyzed by Echinocandin B (HY-125723) deacylase. Echinocandin B nucleus serves as an intermediate for the synthesis of semi-synthetic antifungal agents.
    Echinocandin B nucleus
  • HY-N2552R
    Vitamin K5 hydrochloride (Standard)
    		Inhibitor
    Vitamin K5 (hydrochloride) (Standard) is the analytical standard of Vitamin K5 (hydrochloride). This product is intended for research and analytical applications. Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages[1][2][3].
    Vitamin K5 hydrochloride (Standard)
  • HY-17517
    Tiadinil
    		Inhibitor 99.84%
    Tiadinil is a systemic acquired resistance (SAR) inducer, plant elicitor and antifungal agent. Tiadinil promotes the production of herbivore-induced plant volatiles in Camellia sinensis (tea plant). Tiadinil inhibits mycelial growth, spore germination and germ tube elongation of Stagonosporopsis citrulli in vitro. Tiadinil can be used in studies related to vine blight.
    Tiadinil
  • HY-W391940
    (Rac)-Amorolfine hydrochloride
    (Rac)-Amorolfine hydrochloride is the racemic form of Amorolfine hydrochloride. Amorolfine (Ro 14-4767/002) hydrochloride (HY-B0238) is an effective antifungal agent. Amorolfine hydrochloride inhibits the biosynthesis of ergosterol and has research potential for treating onychomycosis caused by Neoscytalidium dimidiatum.
    (Rac)-Amorolfine hydrochloride
  • HY-B2011R
    Flutolanil (Standard)
    		Inhibitor
    Flutolanil (Standard) is the analytical standard of Flutolanil (HY-B2011). This product is intended for research and analytical applications. Flutolanil is a succinate dehydrogenase complex inhibitor and fungicide. Flutolanil blocks electron transfer between the redox center of succinate dehydrogenase and coenzyme Q, inhibits mycelial oxygen consumption, and suppresses mycelial growth. Flutolanil induces acute and sublethal toxicity in zebrafish at different life stages. Flutolanil can be used in studies on plant disease control.
    Flutolanil (Standard)
  • HY-123404
    L-731128
    L-731128 is a novel alkyl citrate. L-731128 can be isolated as a minor component of Sporormiella intermedia (MF 5447, ATCC 20985) fermentations. L-731128 is a potent squalene synthase inhibitor, with an IC50 value of 767 nM.
    L-731128
  • HY-161380
    Antifungal agent 96
    		Inhibitor
    Antifungal agent 96 (Compound WZ-2) is an antifungal agent with good blood-brain barrier permeability and brain penetration. Antifungal agent 96 inhibits the growth of C. neoformans H99 and C. albicans 0304103 with MIC values of 0.016 and 32 μg/mL, respectively.
    Antifungal agent 96
Cat. No. Product Name / Synonyms Application Reactivity