2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-176483
    Antifungal agent 133
    		Inhibitor
    Antifungal agent 133 (compound D2) is an orally active antifungal agent with a MIC80 of 0.13 ug/mL against C.neoformans H99. Antifungal agent 133 can be used for study of cryptococcal meningitis.
    Antifungal agent 133
  • HY-100666R
    Fosfluconazole (Standard)
    		Inhibitor
    Fosfluconazole (Standard) is the analytical standard of Fosfluconazole. This product is intended for research and analytical applications. Fosfluconazole is a proagent of Fluconazole that is widely used as an antifungal agent.
    Fosfluconazole (Standard)
  • HY-138100
    Hyalodendrin
    		Inhibitor
    Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice.
    Hyalodendrin
  • HY-B1884R
    Procymidone (Standard)
    		Inhibitor
    Procymidone (Standard) is the analytical standard of Procymidone. This product is intended for research and analytical applications. Procymidone, a pesticide, is an immunogen hapten that can be combined with cOVA (carrier protein) to produce polyclonal antibodies. Procymidone has antifungal activity.
    Procymidone (Standard)
  • HY-111201
    Iodiconazole
    		Inhibitor
    Iodiconazole (ADKZ) is a new antifungal compound.
    Iodiconazole
  • HY-A0148AR
    Halofantrine hydrochloride (Standard)
    		Inhibitor
    Halofantrine hydrochloride (Standard) is the analytical standard of Halofantrine hydrochloride. This product is intended for research and analytical applications. Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.
    Halofantrine hydrochloride (Standard)
  • HY-118058
    AB5046A
    AB5046A is a novel chlorosis-inducing substance. AB5046A can be isolated from Nodulisporium sp.. AB5046A induces chlorosis against Japanese barnyard millet.
    AB5046A
  • HY-12538R
    Graveoline (Standard)
    		Inhibitor
    Graveoline (Standard) is the analytical standard of Graveoline (HY-12538). This product is intended for research and analytical applications. Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candida albicans. Graveoline can be used in the research of various diseases such as tumors and liver injury.
    Graveoline (Standard)
  • HY-163688
    Quindecamine acetate
    		Inhibitor
    Quindecamine acetate is a derivative of Quinaldine. Quindecamine acetate has antifungal activity.
    Quindecamine acetate
  • HY-N13156
    Amycolatopsin B
    		Inhibitor
    Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494.
    Amycolatopsin B
  • HY-N14838
    Neoenactin A
    		Inhibitor
    Neoenactin A has strong anti-yeastlike and filamentous fungal effects.
    Neoenactin A
  • HY-106541R
    Neticonazole (Standard)
    		Inhibitor
    Neticonazole (Standard) is the analytical standard of Neticonazole. This product is intended for research and analytical applications. Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects.
    Neticonazole (Standard)
  • HY-N15600
    Merulidial
    		Inhibitor
    Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .
    Merulidial
  • HY-183872
    FTR1335
    		Inhibitor
    FTR1335 is an Antifungal agent as well as a selective, substrate peptide-competitive, and myristoyl-CoA non-competitive inhibitor of N-myristoyltransferase CaNmt, with an IC50 of 0.49 nM against Candida albicans CaNmt. FTR1335 exhibits fungicidal activity against Candida albicans and inhibits the growth of Candida tropicalis. FTR1335 can be used in research related to Candida albicans infections.
    FTR1335
  • HY-117092
    BE-31405
    		Inhibitor
    BE-31405 is an antifungal antibiotic. BE-31405 can be isolated from the culture broth of the fungal strains such as Penicillium minioluteum F31405, Talaromyces siamensis FKA-61, and Phomopsis sp. FKA-62. BE-31405 exhibits potent growth inhibitory activity against pathogenic fungal strains including Candida albicans, Candida glabrata, and Cryptococcus neoformans. BE-31405 shows no cytotoxicity against mammalian cells.
    BE-31405
  • HY-136355R
    Picoxystrobin (Standard)
    		Inhibitor
    Picoxystrobin (Standard) is the analytical standard of Picoxystrobin (HY-136355). This product is intended for research and analytical applications. Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity.
    Picoxystrobin (Standard)
  • HY-12638R
    Dichlorophen (Standard)
    		Inhibitor
    Dichlorophen (Standard) is the analytical standard of Dichlorophen (HY-12638). This product is intended for research and analytical applications. Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections.
    Dichlorophen (Standard)
  • HY-N8432R
    Dipyrithione (Standard)
    		Inhibitor
    Dipyrithione (Standard) is the analytical standard of Dipyrithione (HY-N8432). This product is intended for research and analytical applications. Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis.
    Dipyrithione (Standard)
  • HY-N14679
    Pinselin
    		Inhibitor
    Pinselin is a nitrogen-containing heterocyclic antibiotic. Pinselin has anti-yeast activity.
    Pinselin
  • HY-N12056
    Cyclo(L-leucyl-L-valyl)
    		99.35%
    Cyclo(L-leucyl-L-valyl) inhibits Aflatoxin production by Aspergillus parasiticus.Cyclo(L-leucyl-L-valyl) inhibits transcription of the Aflatoxin-related genes aflR, hexB, pksL1, and dmtA..
    Cyclo(L-leucyl-L-valyl)
Cat. No. Product Name / Synonyms Application Reactivity