2. Others Anti-infection Membrane Transporter/Ion Channel Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reference Standards Parasite Fungal Potassium Channel Reactive Oxygen Species (ROS)
  4. Halofantrine hydrochloride (Standard)

Halofantrine hydrochloride (Standard)  (Synonyms: SKF-102886 (Standard); WR-171669 hydrochloride (Standard))

Cat. No.: HY-A0148AR
Handling Instructions Technical Support

Halofantrine hydrochloride (Standard) is the analytical standard of Halofantrine hydrochloride. This product is intended for research and analytical applications. Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.

For research use only. We do not sell to patients.

Halofantrine hydrochloride (Standard)

Halofantrine hydrochloride (Standard) Chemical Structure

CAS No. : 36167-63-2

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Information

Halofantrine hydrochloride (Standard) is the analytical standard of Halofantrine hydrochloride. This product is intended for research and analytical applications. Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

536.88

Formula

C26H31Cl3F3NO
CAS No.
SMILES

OC(CCN(CCCC)CCCC)C1=CC2=C(Cl)C=C(Cl)C=C2C3=CC(C(F)(F)F)=CC=C31.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Halofantrine hydrochloride (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Halofantrine hydrochloride (Standard)36167-63-2SKF-102886 (Standard) WR-171669 hydrochloride (Standard)Reference StandardsParasiteFungalPotassium ChannelReactive Oxygen Species (ROS)KcsAInhibitorinhibitorinhibit

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