2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. GABA Receptor

GABA Receptor

Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor

GABA Receptor

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GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-100124
    Bamaluzole
    		Agonist
    Bamaluzole is a GABA receptor agonist extracted from patent WO 2012064642 A1.
    Bamaluzole
  • HY-106670
    Dulozafone
    		Activator
    Dulozafone (F1933) shows anticonvulsant activity and can be used for epilepsy research.
    Dulozafone
  • HY-111481
    Flutazolam
    Flutazolam (MS 4101; Ro 7-6102) is a medicine acts on benzodiazepine receptors of the brain and relieves anxiety or tension.
    Flutazolam
  • HY-129105A
    Chlormethiazole (edisylate)
    Chlormethiazole (edisylate) is a sedative-hypnotic with active allosteric modulatory activity at GABAA receptors.
    Chlormethiazole (edisylate)
  • HY-B0007S2
    Baclofen-d5 hydrochloride
    		Agonist
    Baclofen-d5 hydrochloride is deuterated labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research.
    Baclofen-d<sub>5</sub> hydrochloride
  • HY-168977
    Inidascamine
    		Modulator
    Inidascamine is the modulator for cholinergic, glutamatergic, and GABAB receptor, and can be used for researchs of schizophrenia.
    Inidascamine
  • HY-123301
    GABAB receptor antagonist 2
    		Antagonist
    GABAB receptor antagonist 2 is a GABAB receptor/b> antagonist.
    GABAB receptor antagonist 2
  • HY-D1704
    Bodipy TMR-X muscimol
    		Agonist 99.79%
    Bodipy TMR-X muscimol is a Bodipy labeled Muscimol (HY-N2313) (Ex=543 nm, Em=572 nm). Muscimol is a GABAA agonist. Bodipy TMR-X muscimol can be used for imaging the spread of reversible brain inactivations.
    Bodipy TMR-X muscimol
  • HY-105567A
    Carbiphene hydrochloride
    		Antagonist
    Carbiphene hydrochloride is a GABAA receptor allosteric modulator. Carbiphene hydrochloride inhibits [35S] TBPS binding and enhances [3H] muscimol binding on rat forebrain membranes, acting on specific GABAA receptor subsets. Carbiphene hydrochloride can be used in research related to schizophrenia.
    Carbiphene hydrochloride
  • HY-131997
    2'MeO6MF
    		Agonist
    2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response.
    2'MeO6MF
  • HY-133596
    12,14-Dichlorodehydroabietic acid
    		Antagonist
    12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release.
    12,14-Dichlorodehydroabietic acid
  • HY-100783A
    (+)-Bicuculline methochloride
    		Antagonist
    (+)-Bicuculline methobromide is a potent GABAA blocker. (+)-Bicuculline methobromide alters membrane properties and firing pattern. (+)-Bicuculline methobromide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. (+)-Bicuculline methobromide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current.
    (+)-Bicuculline methochloride
  • HY-W743264
    17β-Estradiol sulfate-d6 sodium
    17β-Estradiol sulfate-d3 sodium (17β-Estradiol 3-sulfate-d3 sodium) is the deuterium labeled 17β-Estradiol sulfate sodium (HY-141672). 17β-Estradiol sulfate sodium, also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid.
    17β-Estradiol sulfate-d<sub>6</sub> sodium
  • HY-A0177
    Fominoben
    Fominoben is a type of benzamide-based antitussive agent. Fominoben works by acting on the central nervous system to increase alveolar ventilation, thereby improving the blood oxygen levels in patients with pulmonary diseases (COLD). Fominoben can bind to the benzodiazepine receptor binding sites in the brain and also has anti-anxiety and anti-convulsant effects. Fominoben can be used in research on hypoxemia.
    Fominoben
  • HY-118490
    T-2000
    		Agonist
    T-2000 (DMMDPB) is an orally active GABA receptor agonist with anticonvulsant activities.
    T-2000
  • HY-173251S
    ENX-101
    		Modulator
    ENX-101 is an orally active (GABAA) receptor partial positive allosteric modulator (PAM). ENX-101 is selective to α2β2γ2L (EC50 = 0.76 nM), α2β3γ2L (EC50 = 0.61 nM), α3 (EC50 = 1.97 nM), α5 (EC50 = 0.85 nM) subunits of GABA receptor. ENX-101 possesses antiseizure activity in several animal models.
    ENX-101
  • HY-149400
    GABA-IN-2
    		Inhibitor
    GABA-IN-2 (Compound 5) is a GABA inhibitor. GABA-IN-2 has larvicidal activity and insecticidal effect, with mortality rates of 87% at 50 mg/L.
    GABA-IN-2
  • HY-155305
    BuChE-IN-9
    		Inhibitor
    BuChE-IN-9 (compound 22a) is a potent equine serum-derived BuChE (eqBuChE) inhibitor with an IC50 of 173 nM. BuChE-IN-9 also inhibits human BACE1, Aβ aggregation, mouse GABA transporter 1 (mGAT1) and mGAT4. BuChE-IN-9 has significant antiamnesic properties.
    BuChE-IN-9
  • HY-N2482
    Guvacine
    		Inhibitor
    Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively.
    Guvacine
  • HY-120146
    NNC 05-2090
    		Inhibitor
    NNC 05-2090 is aGABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50 sub>: 10.6 μM). NNC 05-2090 also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases.
    NNC 05-2090
Cat. No. 상품명 / Synonyms Application Reactivity