Carbiphene hydrochloride
Carbiphene hydrochloride is a GABAA receptor allosteric modulator. Carbiphene hydrochloride inhibits [35S] TBPS binding and enhances [3H] muscimol binding on rat forebrain membranes, acting on specific GABAA receptor subsets. Carbiphene hydrochloride can be used in research related to schizophrenia.
For research use only. We do not sell to patients.
- CAS No.: 467-22-1
- Formula: C28H35ClN2O2
- Molecular Weight:467.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Carbiphene hydrochloride inhibits the binding of [35S]TBPS to rat whole forebrain membranes with an IC50 of 12 μM[1].
Carbiphene hydrochloride enhances the binding of [3H]MUS to rat whole forebrain membranes, with an EC50 of 34 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 467-22-1
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Molecular Weight 467.04
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Formula C28H35ClN2O2
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SMILES
O=C(C(OCC)(C1=CC=CC=C1)C2=CC=CC=C2)N(CCN(CCC3=CC=CC=C3)C)C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Squires RF, et al. Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research. Neurochem Res. 2000;25(12):1587-1601. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carbiphene hydrochloride Related Classifications
HY-105567A Related Classifications
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