467-22-1
467-22-1
Chemical Structure
Carbiphene hydrochloride
- CAS No.: 467-22-1
- Formula:C28H35ClN2O2
- Molecular Weight:467.04
IUPAC Name: 2-ethoxy-N-methyl-N-(2-(methyl(phenethyl)amino)ethyl)-2,2-diphenylacetamide hydrochloride
InChIKey: DQPNQXUUCWOWCK-UHFFFAOYSA-N
SMILES: O=C(C(OCC)(C1=CC=CC=C1)C2=CC=CC=C2)N(CCN(CCC3=CC=CC=C3)C)C.Cl
Biological Activity: Carbiphene hydrochloride is a GABAA receptor allosteric modulator. Carbiphene hydrochloride inhibits [35S] TBPS binding and enhances [3H] muscimol binding on rat forebrain membranes, acting on specific GABAA receptor subsets. Carbiphene hydrochloride can be used in research related to schizophrenia[1].
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Carbiphene hydrochloride | Carbiphene hydrochloride is a GABAA receptor allosteric modulator. Carbiphene hydrochloride inhibits [35S] TBPS binding and enhances [3H] muscimol binding on rat forebrain membranes, acting on specific GABAA receptor subsets. Carbiphene hydrochloride can be used in research related to schizophrenia. | |||||||||||||||||||||
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References
- [1]. Squires RF, et al. Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research. Neurochem Res. 2000;25(12):1587-1601. [Content Brief]
