1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Guvacine

Guvacine 

Cat. No.: HY-N2482
Handling Instructions

Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively.

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Guvacine Chemical Structure

Guvacine Chemical Structure

CAS No. : 498-96-4

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Description

Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].

IC50 & Target

IC50: 39 μM (rat GAT-1), 58 μM (rat GAT-2), 378 μM (rat GAT-3), 14 μM (human GAT-1), 119 μM (huam GAT-3) and 1870 μM (human BGT-3)[1]

Molecular Weight

127.14

Formula

C₆H₉NO₂

CAS No.

498-96-4

SMILES

O=C(C1=CCCNC1)O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GuvacineGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGAT-1GAT-2GAT-3BGT-1β-alaninealanineanticonvulsantInhibitorinhibitorinhibit

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