1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Bodipy TMR-X muscimol

Bodipy TMR-X muscimol 

Cat. No.: HY-D1704
Handling Instructions

Bodipy TMR-X muscimol is a Bodipy labeled Muscimol (HY-N2313) (Ex=543 nm, Em=572 nm). Muscimol is a GABAA agonist. Bodipy TMR-X muscimol can be used for imaging the spread of reversible brain inactivations.

For research use only. We do not sell to patients.

Bodipy TMR-X muscimol Chemical Structure

Bodipy TMR-X muscimol Chemical Structure

CAS No. : 849464-08-0

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Description

Bodipy TMR-X muscimol is a Bodipy labeled Muscimol (HY-N2313) (Ex=543 nm, Em=572 nm). Muscimol is a GABAA agonist. Bodipy TMR-X muscimol can be used for imaging the spread of reversible brain inactivations[1].

IC50 & Target

GABAA receptor[1]

In Vivo

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs)[2].
1. Rats are infused with Bodipy TMR-X muscimol as below: dilute the stock solution to 2 μg/μL (in PBS), infused into both hemispheres at a rate of 0.25 μL/min for a single minute, resulting in a final infusion volume of 0.25 μL and a final dose of 0.5 μg per side.
2. The animals are sacrificed by rapid decapitation 15 min after infusion in order to match the spread to what the experimental animals received immediately prior to behavioral testing.
3. The brains are removed and flash frozen in −45°C isopentane, stored at −80°C.
4. Coronal slices are sectioned at 60 μm. The slices are mounted on charged microscope slides and counterstained with DAPI.
5. The stained slices are incubated in a cool, dark room at room temperature for 3 d before being visualized with a confocal microscope.
6. A digital plate from the Paxinos and Watson (2007) rat brain atlas is overlaid on the image to visualize the spread.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

607.46

Formula

C31H36BF2N5O5

CAS No.
SMILES

[F-][B+3]1([N-]2C(C=C(C(C)=C3CCC(NCCCCCC(NCC4=CC(O)=NO4)=O)=O)[N]1=C3C)=CC=C2C5=CC=C(OC)C=C5)[F-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Bodipy TMR-X muscimol
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HY-D1704
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