2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glycosidase

Glycosidase

Glycosidase

Glycosidase

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Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-149409
    α-Glucosidase-IN-31
    		Inhibitor
    α-Glucosidase-IN-31 (compound R1) is an orally active, potent α-Glucosidase inhibitor with an IC50 value of 10.1 μM. α-Glucosidase-IN-31 significantly reduces the blood glucose level and has antidiabetic activity.
    α-Glucosidase-IN-31
  • HY-181091
    α-Glucosidase-IN-109
    		Inhibitor
    α-Glucosidase-IN-109 is an orally active α-glucosidase inhibitor with an IC50 of 0.0136 μM. α-Glucosidase-IN-109 modulates carbohydrate and lipid metabolism, reduces fasting blood glucose levels, alleviates weight loss, and exhibits protective effects on liver and kidney function. α-Glucosidase-IN-109 can be used in research related to type 2 diabetes.
    α-Glucosidase-IN-109
  • HY-180275
    α-Glucosidase-IN-107
    		Inhibitor
    α-Glucosidase-IN-107 (Compound 1) is an α-glucosidase inhibitor with an IC50 of 1.01 μM. α-Glucosidase-IN-107 binds to the allosteric site of α-glucosidase. α-Glucosidase-IN-107 shows non-cytotoxic to normal lung fibrolast cells.
    α-Glucosidase-IN-107
  • HY-138815S
    (S)-N-(1H-Indole-3-acetyl)tryptophan-d4
    		Inhibitor
    (S)-N-(1H-Indole-3-acetyl)tryptophan-d4 is deuterium labeled (S)-N-(1H-Indole-3-acetyl)tryptophan. (S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase.
    (S)-N-(1H-Indole-3-acetyl)tryptophan-d<sub>4</sub>
  • HY-101779A
    DCG04 isomer-1
    DCG04 isomer-1 is an isomer of DCG04 (HY-101779). DCG04 is a multivalent ligand for the mannose-6-phosphate receptor. DCG-04 is an activity-based probe for cysteine cathepsins, and can be used for labelling numerous cysteine cathepsins in cell and tissue lysates.
    DCG04 isomer-1
  • HY-N8947
    Glyurallin A
    		Inhibitor
    Glyurallin A (Compound 79) is isolated from the naturalGlycyrrhiza uralensis. Glyurallin A inhibitsα-Glucosidase(HY-P2802)(IC50=0.3 μM). Glyurallin A can be used in the study of anti-diabetes.
    Glyurallin A
  • HY-14929S
    Migalastat-d2 hydrochloride
    		Inhibitor
    Migalastat-d2 hydrochloride (GR181413A-d2) is the deuterium labeled Migalastat hydrochloride (HY-14929A). Migalastat (GR181413A free base) is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity.
    Migalastat-d<sub>2</sub> hydrochloride
  • HY-N9821
    Giffonin P
    Giffonin P is a selective inhibitor targeting α-glucosidase with an IC50 of 55.3 μM. Giffonin P delays carbohydrate hydrolysis and glucose absorption, exerting anti-hyperglycemic activity. Giffonin P reduces postprandial blood glucose levels and is primarily used in research on type 2 diabetes.
    Giffonin P
  • HY-N7729
    Sekikaic acid
    		Inhibitor
    Sekikaic acid is an α-glucosidase (Glucosidase) and α-amylase (Amylases) inhibitor with hypolipidemic, antioxidant and antidiabetic activities. Sekikaic acid significantly reduces LDL, total cholesterol, and total glyceride levels and causes pancreatic beta cell regeneration.
    Sekikaic acid
  • HY-153592
    Therapeutic agent-1
    Therapeutic agent-1 is a heteroaryl compound that can be used in Gaucher disease glucocerebrosidase activity enzyme replacement therapy.
    Therapeutic agent-1
  • HY-178742
    α-Glucosidase-IN-99
    		Inhibitor
    α-Glucosidase-IN-99 (Compound 21) is an α-Glucosidase inhibitor, with an IC50 of 52.79 μM. α-Glucosidase-IN-99 can be used for the study of type 2 diabetes.
    α-Glucosidase-IN-99
  • HY-N19683
    Kaempferol-3-O-a-L-(3'',4''-di-Z-p-coumaroyl)-rhamnopyranoside
    		Inhibitor
    Kaempferol-3-O-a-L-(3'',4''-di-Z-p-coumaroyl)-rhamnopyranoside is a 3-O-(coumaroyl-rhamnopyranosyl)-flavonol compound found in the leaf extract of Machilus philippinense Merr..
    Kaempferol-3-O-a-L-(3'',4''-di-Z-p-coumaroyl)-rhamnopyranoside
  • HY-E70881
    Endoglycosidase F3 (D165A mutant)
    Endoglycosidase F3 (D165A mutant) (EndoF3 D165A) is a mutant endoglycosidase, which efficiently and specifically recognizes core fucose and O-GlcNAc.
    Endoglycosidase F3 (D165A mutant)
  • HY-P2775D
    β-Glucosidase, Bacteroides fragilis
    β-Glucosidase, Bacteroides fragilis (EC 3.2.1.21), is a glucosidase that acts on the β1→4 glycosidic bond connecting two glucose molecules or glucose-substituted molecules (e.g., disaccharide cellobiose). β-Glucosidase is an exonuclease specific for a variety of β-D-glycosidic substrates. β-Glucosidase catalyzes the hydrolysis of the terminal non-reducing residues of β-D-glucosides, releasing glucose.
    β-Glucosidase, Bacteroides fragilis
  • HY-N0057R
    3,4-Dicaffeoylquinic acid (Standard)
    		Inhibitor
    3,4-Dicaffeoylquinic acid (Standard) is the analytical standard of 3,4-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL.
    3,4-Dicaffeoylquinic acid (Standard)
  • HY-174223
    α-Glucosidase-IN-90
    		Inhibitor
    α-Glucosidase-IN-90 (Compound 7b) is an α-Glucosidase inhibitor (IC50: 14.48 nM). α-Glucosidase-IN-90 binds to HIS:280 and ASN:415 residues of α-glucosidase via hydrogen bonds, inhibiting the activity of the enzyme. α-Glucosidase-IN-90 can be used in the study of diabetes.
    α-Glucosidase-IN-90
  • HY-168495
    α-Amylase-IN-12
    		Inhibitor
    α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor (IC50: 0.15 mM) with a mixed inhibition. α-Amylase-IN-12 has an IC50 of 9.40 mM against α-glucosidase. α-Amylase-IN-12 promotes glucose uptake in yeast cells and exhibits significant antiglycation activity at high concentrations. α-Amylase-IN-12 can be used for the research of diabetes.
    α-Amylase-IN-12
  • HY-19332R
    Kifunensine (Standard)
    		Inhibitor
    Bromperidol decanoate (Standard) is the analytical standard of Bromperidol decanoate. This product is intended for research and analytical applications. Bromperidol decanoate (R46541) is a compound used for the inhibition of schizophrenia and has certain clinical inhibitory activity.
    Kifunensine (Standard)
  • HY-181891
    XAT-13
    		Inhibitor
    XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases.
    XAT-13
  • HY-175605
    α-Amylase/α-Glucosidase-IN-21
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-21 (Compound 4) is a dual-functional inhibitor of α-Glucosidase and α-Amylase with IC50s of 0.27 and  0.19 µg/mL for α-Glucosidase and α-Amylase, respectively. α-Amylase/α-Glucosidase-IN-21 has an antidiabetic activity.α-Amylase/α-Glucosidase-IN-21 can be used for diabetes mellitus research.
    α-Amylase/α-Glucosidase-IN-21
Cat. No. Product Name / Synonyms Application Reactivity