α-Glucosidase-IN-109
α-Glucosidase-IN-109 is an orally active α-glucosidase inhibitor with an IC50 of 0.0136 μM. α-Glucosidase-IN-109 modulates carbohydrate and lipid metabolism, reduces fasting blood glucose levels, alleviates weight loss, and exhibits protective effects on liver and kidney function. α-Glucosidase-IN-109 can be used in research related to type 2 diabetes.
For research use only. We do not sell to patients.
- Formula: C16H13Cl2NO2
- Molecular Weight:322.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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α‑glucosidase 0.0136 μM (IC50) |
α-Glucosidase-IN-109 (Compound 2l) (50 min) potently inhibits α-glucosidase from Saccharomyces cerevisiae, with an IC50 value of 0.0136 μM[1].
α-Glucosidase-IN-109 exhibits good metabolic stability in human and rat liver microsomes, with half-lives of 135.8 min and 52.1 min, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KM (male, 4 weeks old, 16-20 g, T2DM model via high-fat diet + STZ (HY-13753) injection)[1]
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Dosage:15 mg/kg
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Administration:oral gavage; daily; 4 weeks
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Result:Significantly reduced fasting blood glucose.
Attenuated weight loss.
Improved glucose tolerance, reduced serum TC, TG, LDL-C levels, increased HDL-C levels.
Reduced serum ALT and AST levels (restoring liver function) and decreased serum CRE and BUN levels (reducing renal injury).
Elevated insulin concentration.
Restored liver tissue architecture (reduced vacuolization, inflammatory cell infiltration, and hepatocyte hypertrophy) on HE staining.
Chemical Information
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Molecular Weight 322.19
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Formula C16H13Cl2NO2
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SMILES
ClC1=CC(CNC(/C=C/C2=CC=C(O)C=C2)=O)=CC(Cl)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Glucosidase-IN-109 Related Classifications
HY-181091 Related Classifications
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