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Cat. No.: HY-14929S

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Migalastat-d₂ hydrochloride

(Synonyms: GR181413A-d₂)

Migalastat-d₂ hydrochloride (GR181413A-d₂) is the deuterium labeled Migalastat hydrochloride (HY-14929A). Migalastat (GR181413A free base) is an orally active α-galactosidase A molecular chaperone, with an IC₅₀ value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity.

For research use only. We do not sell to patients.

Formula: C₆H₁₂D₂ClNO₄
Molecular Weight:201.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Migalastat-d₂ hydrochloride Chemical Structure

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
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Biological Activity

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 75172-81-5
Molecular Weight 201.64
Formula C₆H₁₂D₂ClNO₄
SMILES

O[C@H]1[C@@H](CO)NC([2H])([2H])[C@H](O)[C@H]1O.Cl
Synonyms

GR181413A-d₂
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.