Migalastat hydrochloride-15N
Migalastat hydrochloride-15N (GR181413A-15N) is the 15N-labeled Migalastat hydrochloride (HY-14929A). Migalastat (GR181413A free base) hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity.
For research use only. We do not sell to patients.
- CAS No.: 1219134-37-8
- Formula: C6H14Cl15NO4
- Molecular Weight:200.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219134-37-8
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Unlabeled Cas 75172-81-5
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Molecular Weight 200.63
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Formula C6H14Cl15NO4
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SMILES
O[C@H]1[C@H]([C@H]([15NH]C[C@@H]1O)CO)O.Cl
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Synonyms
GR181413A-15N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)