2. シグナル伝達
  3. NF-κB
  4. NF-κB
  5. NF-κB1/p50 Isoform

NF-κB1/p50

NF-κB1/p50 is generated from the NFKB1 product through 26S proteasome-dependent cotranslational processing and forms DNA-binding NF-κB dimers, including the prototypical p50:RelA/p65 complex[1][2]. Mechanistically, p50 supports inflammatory-response control because p50 homodimers activate IL-10 transcription in macrophages and p50-deficient macrophages show decreased IL-10 with increased TNF and IL-12 after LPS stimulation[3]. In chronic liver injury models, loss of nfkb1 causes more severe neutrophilic inflammation and fibrosis, linking p50 to restraint of TNF-α-driven tissue damage[4]. Compared with RelA/p65, RelB, and c-Rel, p50 lacks a transactivation domain, so p50:p50 complexes often function through cofactors rather than direct transcriptional activation[2]. In activated hepatic stellate cells, the p50:p50:HDAC1 complex represses Ccl2, Cxcl10, Gm-csf, and Mmp-13, defining a disease-relevant anti-inflammatory NF-κB1/p50 mechanism[5]. For experimental applications, BCL-3-p50 biology provides a modifiable axis because a BCL-3-mimetic peptide was designed from the ANK1 region that interacts with p50[6].

NF-κB1/p50 関連製品 (8):

製品番号 製品名 製品効果 純度
  • HY-125864
    Fibrinogen (Bovine) Activator
    Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases.
  • HY-N0191
    Andrographolide Inhibitor 99.74%
    Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.
  • HY-N0290
    Mangiferin Inhibitor 99.92%
    Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities.
  • HY-14592
    Tectochrysin Inhibitor 99.88%
    Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin inhibits activity of NF-κB.
  • HY-174138
    NF-κB degrader 1 Degrader 99.92%
    NF-κB degrader 1 (Compound MD-1) is a NF-κB1 p105 subunit degrader. NF-κB degrader 1 shows anti-inflammatory activity (IC50 for inhibiting TNF-α is 2.02 μM, and for inhibiting NO is 5.40 μM). NF-κB degrader 1 induces p105 degradation dependent on the Cullin-RING ligase (CRL) SCFBTCP, suppressing NF-κB transcriptional activity. NF-κB degrader 1 is promising for research of inflammation-related diseases.
  • HY-P10030
    DPLG3 Inhibitor 99.18%
    DPLG3 is a specific chymotryptic-like β5i subunits inhibitor, with an IC50 of 4.5 nM. DPLG3 inhibits mouse i-20S with IC50 of 9.4 nM. DPLG3 downregulates the protein levels of NF-κB p50 and p65. DPLG3 can be used for immune disease research.
  • HY-N3364
    Lucidone Inhibitor
    Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM).
  • HY-175397
    Dth Degrader
    Dth (DFHBI-thalidomide) is an RNA aptamer-based PROTAC degrader. Dth can degrade a variety of endogenous proteins (such as mCherry, p50, p65 and E2F1) by replacing the 3′ module on the RNA scaffold with the RNA aptamer corresponding to the target protein. Dth upregulates IκB-α and Bax, and downregulates Bcl-2 and VEGF. Dth generates green fluorescence upon binding to the Broccoli RNA aptamer, enabling the tracing of RNA scaffolds. Dth can be used in cancer-related research.
製品番号 製品名 / Synonyms Application Reactivity