2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Related Products

PDF 4.17 MB

Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.

Phosphodiesterase (PDE) Isoform Specific Products:

Phosphodiesterase (PDE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125251
    D159153
    		Inhibitor
    D159153 is a highly selective phosphodiesterase 4 (PDE4) inhibitor. D159153 is promising for research of asthma, chronic obstructive pulmonary disease (COPD), and neuroinflammatory disorders.
    D159153
  • HY-165441
    R-836
    		Inhibitor
    R-836 is an orally active bronchodilator. R-836 is also a weak phosphodiesterase inhibitor. R-836 can reduce bronchoconstriction caused by antigens or platelet-activating factor. R-836 prevents asphyxiation or dyspnea.
    R-836
  • HY-P2878A
    Phosphodiesterase l, Rattlesnake venom
    Phosphodiesterase l, Rattlesnake venom (PDE, Rattlesnake venom) is a non-selective phosphodiester bond hydrolase targeting phosphodiester bonds in oligonucleotides, catalyzing their hydrolysis into mononucleotides. Phosphodiesterase l, Rattlesnake venom cleaves phosphodiester linkages in DNA fragments digested by DNase I. Phosphodiesterase l, Rattlesnake venom is promising for research of nucleic acid structure and metabolism.
    Phosphodiesterase l, Rattlesnake venom
  • HY-A0140
    Drotaverine
    Drotaverine is a selective phosphodiesterase 4 inhibitor with angina relief activity. Drotaverine is used to suppress angina, including pain in the gastrointestinal tract and biliary tract. Drotaverine may also cause compound-induced priapism, a side effect of sustained penile erection.
    Drotaverine
  • HY-176235
    PDE5-IN-14
    		Inhibitor
    PDE5-IN-14 (Compound 14a) is a brain-penetrant competitive phosphodiesterase 5 (PDE5) inhibitor (IC50=16.11 nM). PDE5-IN-14 is promising for research of Alzheimer’s disease (AD), cancer and cardiovascular diseases.
    PDE5-IN-14
  • HY-119855S1
    Aildenafil-d5
    		Inhibitor
    Aildenafil-d5 (Methisosildenafil-d5) is the deuterium labeled Aildenafil (HY-119855). Aildenafil (Methisosildenafil) is a PDE-5 inhibitor that can induce vasodilation by increasing NO levels.
    Aildenafil-d<sub>5</sub>
  • HY-143419
    ATX inhibitor 14
    		Inhibitor
    ATX inhibitor 14 (compound 4), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 0.41 nM. ATX inhibitor 14 has the potential for fibrosis relevant diseases research.
    ATX inhibitor 14
  • HY-142660
    PDE2A-IN-1
    		Inhibitor
    PDE2A-IN-1 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC50 value of 1.3 nM.
    PDE2A-IN-1
  • HY-105096
    Arofylline
    		Inhibitor
    Arofylline is a PDE4 inhibitor as a potential research for asthma.
    Arofylline
  • HY-176828
    Enpp-1-IN-28
    		Inhibitor
    Enpp-1-IN-28 is a ENPP1 inhibitor at the molecular and cellular levels, with IC50 values of 0.188 µM and 0.732 µM, respectively. Enpp-1-IN-28 upgrades the expression levels of IFN-β in vivo by preventing the ENPP1 from hydrolyzing the cGAMP to stimulate a more potent innate immune response. Enpp-1-IN-28 can be used for the study of metastatic breast cancer.
    Enpp-1-IN-28
  • HY-N6256
    Ilexsaponin B2
    		Inhibitor
    Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook. et Arn. Ilexsaponin B2 is a potent phosphodiesterase 5 (PDE5) and PDEI inhibitor with IC50 values of 48.8 μM and 477.5 μM, respectively.
    Ilexsaponin B2
  • HY-123637
    Autotaxin-IN-1
    		Inhibitor
    Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.
    Autotaxin-IN-1
  • HY-179645
    Phosphodiesterase-IN-5
    		Inhibitor
    Phosphodiesterase-IN-5 is a potent, orally active and selective phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 6.2 nM. Phosphodiesterase-IN-5 shows >1612-fold selectivity over other PDEs. Phosphodiesterase-IN-5 exhibits potent antifibrotic efficacy in a Bleomycin (BLM) (HY-108345)-induced murine model of pulmonary fibrosis (PF) by blocking myofibroblast differentiation via the cAMP/PKA/CREB signaling pathway. Phosphodiesterase-IN-5 can be used for the research of PF.
    Phosphodiesterase-IN-5
  • HY-143581
    ATX inhibitor 8
    		Inhibitor
    ATX inhibitor 8 is a Autotaxin (ATX) inhibitor extracted from patent WO2018212534A1 compound 96.
    ATX inhibitor 8
  • HY-103160B
    EHNA
    		Inhibitor
    EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects.
    EHNA
  • HY-146974
    PDE4-IN-9
    		Inhibitor
    PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS.
    PDE4-IN-9
  • HY-162581
    FCPR16
    		Inhibitor
    FCPR16 is a Phosphodiesterase 4 (PDE4) inhibitor. FCPR16 increases the levels of cAMP in SH-SY5Y cells. FCPR16 can be used in the study of Parkinson's disease.
    FCPR16
  • HY-125050
    KCA-1490
    		Inhibitor
    KCA-1490 is a dual PDE3/4 inhibitor with IC50 values of 369 nM and 42 nM, respectively. KCA-1490 exhibits potent bronchodilatory and anti-inflammatory activity. KCA-1490 suppresses Histamine (HY-B1204)-induced bronchoconstriction in vivo, which is promising for research of asthma and chronic obstructive pulmonary disease (COPD).
    KCA-1490
  • HY-134937
    BC8-15
    		Inhibitor
    BC8-15 is a PDE inhibitor with IC50 values of 0.28, 0.22, and 6.46 µM for inhibiting PDE8A, PDE4A, and PDE7A, respectively. BC8-15 can enhance steroidogenesis in mouse Leydig cells.
    BC8-15
  • HY-12085S2
    (Rac)-Apremilast-d5
    (Rac)-Apremilast-d5 is a deuterium labeled (R)-Apremilast. (R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast.
    (Rac)-Apremilast-d<sub>5</sub>
Cat. No. Product Name / Synonyms Application Reactivity
Phosphodiesterase (PDE) Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.