Phosphodiesterase (PDE)
Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.
Phosphodiesterase (PDE) Isoform Specific Products
-
Phosphodiesterase (PDE)
(547)
View all products
-
PDE1
(60)
View all products
-
PDE2
(51)
View all products
-
PDE3
(93)
View all products
-
PDE4
(197)
View all products
-
PDE5
(97)
View all products
-
PDE6
(22)
View all products
-
PDE7
(28)
View all products
-
PDE9
(19)
View all products
-
PDE10
(53)
View all products
-
PDE11
(13)
View all products
-
PDE12
(2)
View all products
-
PDE8
(11)
View all products
-
Autotaxin
(36)
View all products
All Product Categories
-
Phosphodiesterase (PDE) Inhibitors
(908)
View all products
-
Phosphodiesterase (PDE) Agonists
(3)
View all products
-
Phosphodiesterase (PDE) Antagonists
(3)
View all products
-
Phosphodiesterase (PDE) Activators
(7)
View all products
-
Phosphodiesterase (PDE) Modulators
(8)
View all products
-
Phosphodiesterase (PDE) Degraders
(4)
View all products
-
Phosphodiesterase (PDE) Controls
(8)
View all products
-
Phosphodiesterase (PDE) Substrates
(4)
View all products
-
Phosphodiesterase (PDE) Ligand
(1)
View all products
-
Phosphodiesterase (PDE) Related Products (1002)
Related Products (1002)
-
Antibodies (4)
-
Phosphodiesterase (PDE) Isoform Comparison
-
SCH-1518291
0 ImagesCat. No.: HY-14458CAS No.: 1228244-79-8SCH-1518291 (Compound 27) is an orally active PDE10A inhibitor. SCH-1518291 exhibits antipsychotic activity in an ADHD rat model. SCH-1518291 can be used in research on neurological disorders such as psychosis.
-
Tolafentrine
0 ImagesCat. No.: HY-W700639CAS No.: 139308-65-9Tolafentrine, a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor, has been shown to have significant acute and chronic effects in a unilateral diacetamide-induced rat pulmonary hypertension model. Experiments show that long-term administration can significantly alleviate all unilateral bisacetamide-induced hemodynamic and gas exchange abnormalities, reduce right ventricular hypertrophy, and normalize pulmonary vascular remodeling changes.
-
PDE1-IN-5
0 ImagesCat. No.: HY-155199CAS No.: 2982945-34-4PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC50: 15 nM). PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS)-Induced colitis mice model. PDE1-IN-5 can be used for research of IBD.
-
Ambuphylline
0 ImagesAmbuphylline (Bufylline) is a bronchodilator. Ambuphylline is a theophylline derivative possibly acting through phosphodiesterase inhibition. Ambuphylline can be used for the research of asthma and other lung diseases.
-
Amentoflavone hexaacetate
0 ImagesCat. No.: HY-124371CAS No.: 17482-37-0Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects.
-
PDE10A-IN-3
0 ImagesCat. No.: HY-158237CAS No.: 1006889-85-5PDE10A-IN-3 (Compound 8a) is an inhibitor of phosphodiesterase 10A (PDE10A). PDE10A-IN-3 can be used in schizophrenia research.
-
CBS-3595
0 ImagesCat. No.: HY-111164CAS No.: 908380-97-2CBS-3595 is a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) (HY-153808)-induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases.
-
Aristolochic acid D (Standard)
0 ImagesCat. No.: HY-N1465RCAS No.: 17413-38-6Synonyms: Aristolochic acid-IVa (Standard)Aristolochic acid D (Standard) (Aristolochic acid-IVa (Standard)) is the analytical standard of Aristolochic acid D (HY-N1465). This product is intended for research and analytical applications. Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 (IC50: 4.673 μM) and CDK2 (IC50: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases.
-
PDE4-IN-11
0 ImagesCat. No.: HY-150060CAS No.: 524734-30-3PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 (PDE4). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research.
-
PF-04471141 hydrochloride
0 ImagesCat. No.: HY-122622CAS No.: 1655498-17-1PF-04471141 (hydrochloride) is a compound that regulates intracellular cAMP and cGMP concentrations. It is a PDE1 inhibitor and has different effects on different PDE enzymes in regulating intracellular signaling molecule concentrations and cell proliferation in vascular smooth muscle cells.
-
LY2775240
0 ImagesCat. No.: HY-201403CAS No.: 1628160-15-5LY2775240 is an orally active phosphodiesterase 4 (PDE4) inhibitor with potent inhibitory activity against PDE4A (IC50 = 0.09 nM), PDE4B (IC50 = 0.09 nM) and PDE4D (IC50 = 0.14 nM), and exhibits an IC50 of 2.4 nM against PDE4C. LY2775240 is a highly selective agent that reduces TNFα production upon immune activation. LY2775240 decreases TNFα production in rodent and rhesus monkey models. LY2775240 can be used in the research of psoriasis.
-
Phosphodiesterase-IN-2
0 ImagesCat. No.: HY-161663CAS No.: 3047610-96-5Phosphodiesterase-IN-2 (Compound C7) is a selective, orally active inhibitor for phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. Phosphodiesterase-IN-2 improves the stability of liver microsomes, and lowers BBB permeability. Phosphodiesterase-IN-2 exhibits good pharmacokinetic characters, and attenuates isoprenaline (HY-108353)-induced cardiac hypertrophic in mouse models.
-
GPD-1116
0 ImagesCat. No.: HY-167891CAS No.: 690690-72-3GPD-1116 is an orally active Phosphodiesterase (PDE) 4 and PDE1 inhibitor. GPD-1116 can reduce smoke-induced apoptosis of lung cells. GPD-1116 is effective in several disease models in animals, including emphysema, acute lung injury, chronic obstructive pulmonary disease (COPD), asthma and pulmonary hypertension.
-
ATX inhibitor 19
0 ImagesCat. No.: HY-146122CAS No.: 2691937-01-4ATX inhibitor 19 (compound 22) is a potent ATX (autotaxin) inhibitor, with an IC50 of 156 nM.
-
DNS-8254
0 ImagesCat. No.: HY-120710CAS No.: 1821107-98-5DNS-8254 is an oral active and brain-penetrating PDE2a inhibitor with the IC50 of 8 nM. DNS-8254 shows memory enhancing effects in a rat model.
-
PAT-347 sodium
0 ImagesCat. No.: HY-126233ACAS No.: 2650082-35-0PAT-347 sodium is an Autotaxin (ATX) inhibitor. ATX is a secretory enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates lysophosphatidic acid (LPA) production in the blood.
-
D159153
0 ImagesCat. No.: HY-125251CAS No.: 1158231-00-5D159153 is a highly selective phosphodiesterase 4 (PDE4) inhibitor. D159153 is promising for research of asthma, chronic obstructive pulmonary disease (COPD), and neuroinflammatory disorders.
-
R-836
0 ImagesCat. No.: HY-165441CAS No.: 94415-03-9R-836 is an orally active bronchodilator. R-836 is also a weak phosphodiesterase inhibitor. R-836 can reduce bronchoconstriction caused by antigens or platelet-activating factor. R-836 prevents asphyxiation or dyspnea.
-
Phosphodiesterase l, Rattlesnake venom
0 ImagesPhosphodiesterase l, Rattlesnake venom (PDE, Rattlesnake venom) is a non-selective phosphodiester bond hydrolase targeting phosphodiester bonds in oligonucleotides, catalyzing their hydrolysis into mononucleotides. Phosphodiesterase l, Rattlesnake venom cleaves phosphodiester linkages in DNA fragments digested by DNase I. Phosphodiesterase l, Rattlesnake venom is promising for research of nucleic acid structure and metabolism.
-
Drotaverine
0 ImagesCat. No.: HY-A0140CAS No.: 14009-24-6Drotaverine is a selective phosphodiesterase 4 inhibitor with angina relief activity. Drotaverine is used to suppress angina, including pain in the gastrointestinal tract and biliary tract. Drotaverine may also cause compound-induced priapism, a side effect of sustained penile erection.
