Enpp-1-IN-28
Enpp-1-IN-28 is a ENPP1 inhibitor at the molecular and cellular levels, with IC50 values of 0.188 µM and 0.732 µM, respectively. Enpp-1-IN-28 upgrades the expression levels of IFN-β in vivo by preventing the ENPP1 from hydrolyzing the cGAMP to stimulate a more potent innate immune response. Enpp-1-IN-28 can be used for the study of metastatic breast cancer.
For research use only. We do not sell to patients.
- Formula: C17H13FN4O2S
- Molecular Weight:356.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ENPP1 0.188 μM (IC50, molecular levels) |
ENPP1 0.732 μM (IC50, cellular levels) |
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-231 | IC50 |
<1 μM
Compound: 53
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Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by CCK8 assay
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[PMID: 38359537] |
Enpp-1-IN-28 (Compound 4e) displays cytotoxic activity against 4T1 cell line (IC50 = 2.99 μM), while exerting nonsignificant cytotoxic effect on normal cell lines (LO2 and 293T) at 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4T1 breast cancer cells were subcutaneously implanted into 6-8-week-old BALB/c nude mice[1]
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Dosage:0.5 mg/kg combined with 5 mg/kg cGAMP
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Administration:i.v. for a single dose
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Result:Increased the expression level of IFN-β in the serum of BALB/c nude mice compared with the free cGAMP group.
Protected cGAMP from degradation by ENPP1, thereby stimulating a more potent innate immune response.
Chemical Information
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Molecular Weight 356.37
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Formula C17H13FN4O2S
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SMILES
FC1=CC2=C(C(NC(CSC3=NC4=CC(OC)=CC=C4N3)=N2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Enpp-1-IN-28 Related Classifications
HY-176828 Related Classifications
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