Autotaxin-IN-1
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.
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- CAS. Nr.: 1619971-30-0
- Formel: C21H23N7O2
- Molecular Weight:405.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Autotaxin 2 nM (IC50) |
Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Normal rat[1]
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Dosage:1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study)
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Administration:I.v. (1.0 mg/kg); p.o. (10 mg/kg)
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Result:Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg).
Has Cmax of 660 nM and AUC of 3440 nM▪h (p.o.; 10 mg/kg).
Chemical Information
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CAS. Nr. 1619971-30-0
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Molecular Weight 405.45
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Formel C21H23N7O2
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SMILES
O=C(N1CC2=NC(NC3CC4=C(C=CC=C4)C3)=NC=C2C1)COCCC5=CN=NN5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Autotaxin-IN-1 Related Classifications
HY-123637 Related Classifications
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