Autotaxin-IN-1
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.
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- CAS No.: 1619971-30-0
- Formule: C21H23N7O2
- Masse moléculaire:405.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Autotaxin 2 nM (IC50) |
In Vivo
Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Normal rat[1]
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Dosage:1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study)
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Administration:I.v. (1.0 mg/kg); p.o. (10 mg/kg)
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Result:Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg).
Has Cmax of 660 nM and AUC of 3440 nM▪h (p.o.; 10 mg/kg).
Chemical Information
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CAS No. 1619971-30-0
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Masse moléculaire 405.45
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Formule C21H23N7O2
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SMILES
O=C(N1CC2=NC(NC3CC4=C(C=CC=C4)C3)=NC=C2C1)COCCC5=CN=NN5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Autotaxin-IN-1 Related Classifications
HY-123637 Related Classifications
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