1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Autotaxin-IN-1

Autotaxin-IN-1 

Cat. No.: HY-123637
Handling Instructions

Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.

For research use only. We do not sell to patients.

Autotaxin-IN-1 Chemical Structure

Autotaxin-IN-1 Chemical Structure

CAS No. : 1619971-30-0

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Description

Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain[1].

IC50 & Target[1]

Autotaxin

2 nM (IC50)

In Vivo

Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours[1].
Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM•h[1].

Animal Model: Normal rat[1]
Dosage: 1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study)
Administration: I.v. (1.0 mg/kg); p.o. (10 mg/kg)
Result: Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg).
Has Cmax of 660 nM and AUC of 3440 nM▪h (p.o.; 10 mg/kg).
Molecular Weight

405.45

Formula

C₂₁H₂₃N₇O₂

CAS No.

1619971-30-0

SMILES

O=C(N1CC2=NC(NC3CC4=C(C=CC=C4)C3)=NC=C2C1)COCCC5=CN=NN5

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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