2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Autotaxin-IN-1

Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.

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Autotaxin-IN-1 Chemical Structure

Autotaxin-IN-1 Chemical Structure

CAS No. : 1619971-30-0

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Autotaxin-IN-1 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain[1].

IC50 & Target[1]

Autotaxin

2 nM (IC50)

In Vivo

Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours[1].
Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM•h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Normal rat[1]
Dosage: 1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study)
Administration: I.v. (1.0 mg/kg); p.o. (10 mg/kg)
Result: Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg).
Has Cmax of 660 nM and AUC of 3440 nM▪h (p.o.; 10 mg/kg).
Molecular Weight

405.45

Formula

C21H23N7O2
CAS No.
SMILES

O=C(N1CC2=NC(NC3CC4=C(C=CC=C4)C3)=NC=C2C1)COCCC5=CN=NN5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Autotaxin-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Autotaxin-IN-11619971-30-0Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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